HuLPr46307

Uniprot ID

STEA1_HUMAN

Uniprot Acc

Q9UHE8;A4D1E0;O95034;

Protein name

Metalloreductase STEAP1

Comment

FUNCTION:Metalloreductase that has the ability to reduce both Fe(3+) to Fe(2+) and Cu(2+) to Cu(1+). Uses NAD(+) as acceptor (By similarity).||COFACTOR:FAD (By similarity).||SUBCELLULAR LOCATION:Endosome membrane; Multi-pass membrane protein (By similarity).||TISSUE SPECIFICITY:Ubiquitously expressed. Highly expressed in prostate tumors.||SIMILARITY:Belongs to the STEAP family.||SIMILARITY:Contains 1 ferric oxidoreductase domain.

Subcellular localization

Endosome membrane;Multi-pass membrane protein(By similarity).

Gene name

six transmembrane epithelial antigen of the prostate 1

Protein sequence

MESRKDITNQEELWKMKPRRNLEEDDYLHKDTGETSMLKR PVLLHLHQTAHADEFDCPSELQHTQELFPQWHLPIKIAA IIASLTFLYTLLREVIHPLATSHQQYFYKIPILVINKVL PMVSITLLALVYLPGVIAAIVQLHNGTKYKKFPHWLDKW MLTRKQFGLLSFFFAVLHAIYSLSYPMRRSYRYKLLNWA YQQVQQNKEDAWIEHDVWRMEIYVSLGIVGLAILALLAV TSIPSVSDSLTWREFHYIQSKLGIVSLLLGTIHALIFAW NKWIDIKQFVWYTPPTFMIAVFLPIVVLIFKSILFLPCL RKKILKIRHGWEDVTKINKTEICSQL

Database cross reference

RefSeq Protein accession:NP_036581
RefSeq Protein gi:9558759

HLPP validation

Yes/No

Yes

Project name

French Liver;

GO:0005911;C:cell-cell junction;TAS:ProtInc. GO:0010008;C:endosome membrane;IEA:UniProtKB-SubCell. GO:0005887;C:integral to plasma membrane;TAS:ProtInc.

GO-F

GO:0015267;F:channel activity;TAS:ProtInc. GO:0009055;F:electron carrier activity;IEA:InterPro. GO:0050660;F:flavin adenine dinucleotide binding;IEA:InterPro. GO:0005506;F:iron ion binding;IEA:InterPro. GO:0016491;F:oxidoreductase activity;IEA:UniProtK

GO-P

GO:0022900;P:electron transport chain;IEA:UniProtKB-KW. GO:0006811;P:ion transport;IEA:UniProtKB-KW. GO:0055072;P:iron ion homeostasis;IEA:UniProtKB-KW.

MOD type1

Position1

Residue1

Source name1

source ID1

Source method

HLPP validation1 (Yes/no)

Quality score

HuLPr46307

PHOSPHORYLATION

337

S

PhosphoSitePlus

460775

HTP

N

HuLPr46307

PHOSPHORYLATION

27

Y

PhosphoSitePlus

457844

LTP

N