Protein basic information
| LiverAtlas Protein ID |
HuLPr46309 |
|
Uniprot ID |
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|
Uniprot Acc |
Q658P3;A8K6E3;Q4VBR2;Q4ZG36;Q53SQ8;Q7Z389;Q86SF6;Q8NEW6;Q8TDP3;Q8TF03;Q9NVB5; |
|
Protein name |
Metalloreductase STEAP3 |
|
Comment |
FUNCTION:Endosomal ferrireductase required for efficient transferrin-dependent iron uptake in erythroid cells. Participates in erythroid iron homeostasis by reducing Fe(3+) to Fe(2+). Can also reduce of Cu(2+) to Cu(1+), suggesting that it participates in copper homeostasis. Uses NAD(+) as acceptor (By similarity). May play a role downstream of p53/TP53 to interface apoptosis and cell cycle progression. Indirectly involved in exosome secretion by facilitating the secretion of proteins such as TCTP.||COFACTOR:FAD (By similarity).||SUBUNIT:Interacts with BNIP3L, MYT1 and TCTP.||SUBCELLULAR LOCATION:Endosome membrane; Multi-pass membrane protein (By similarity). Note=Localizes to vesicular-like structures at the plasma membrane and around the nucleus.||ALTERNATIVE PRODUCTS:Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q658P3-1; Sequence=Displayed; Name=2; IsoId=Q658P3-2; Sequence=VSP 024829; Name=3; IsoId=Q658P3-3; Sequence=VSP 024830; Name=4; Synonyms=pHyde II; IsoI |
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Subcellular localization |
Endosome membrane;Multi-pass membrane protein(By similarity). |
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Gene name |
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Protein sequence
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MPEEMDKPLISLHLVDSDSSLAKVPDEAPKVGILGSGDFA RSLATRLVGSGFKVVVGSRNPKRTARLFPSAAQVTFQEE AVSSPEVIFVAVFREHYSSLCSLSDQLAGKILVDVSNPT EQEHLQHRESNAEYLASLFPTCTVVKAFNVISAWTLQAG PRDGNRQVPICGDQPEAKRAVSEMALAMGFMPVDMGSLA SAWEVEAMPLRLLPAWKVPTLLALGLFVCFYAYNFVRDV LQPYVQESQNKFFKLPVSVVNTTLPCVAYVLLSLVYLPG VLAAALQLRRGTKYQRFPDWLDHWLQHRKQIGLLSFFCA ALHALYSFCLPLRRAHRYDLVNLAVKQVLANKSHLWVEE EVWRMEIYLSLGVLALGTLSLLAVTSLPSIANSLNWREF SFVQSSLGFVALVLSTLHTLTYGWTRAFEESRYKFYLPP TFTLTLLVPCVVILAKALFLLPCISRRLARIRRGWERES TIKFTLPTDHALAEKTSHV |
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Database cross reference |
RefSeq Protein accession:NP_001008410
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Liver relevance
|
HLPP validation |
Yes/No |
Yes |
|
Project name |
Chinese Liver;Human Liver Organelles; |
Ontology annotation
| GO-C |
GO:0010008;C:endosome membrane;TAS:Reactome. GO:0016021;C:integral to membrane;IEA:UniProtKB-KW. GO:0005771;C:multivesicular body;IDA:MGI. |
|
GO-F |
GO:0009055;F:electron carrier activity;IEA:InterPro. GO:0050660;F:flavin adenine dinucleotide binding;IEA:InterPro. GO:0005506;F:iron ion binding;IEA:InterPro. |
|
GO-P |
GO:0006915;P:apoptosis;IEA:UniProtKB-KW. GO:0007049;P:cell cycle;IEA:UniProtKB-KW. GO:0006879;P:cellular iron ion homeostasis;TAS:Reactome. GO:0055114;P:oxidation-reduction process;IEA:UniProtKB-KW. GO:0009306;P:protein secretion;IDA:MGI. GO:0033572;P |
Post-translational modification
| LiverAtlas Protein ID |
MOD type1 |
Position1 |
Residue1 |
Source name1 |
source ID1 |
Source method |
HLPP validation1 (Yes/no) |
Quality score |
|
HuLPr46309 |
PHOSPHORYLATION |
17 |
S |
Phospho-ELM |
HTP |
yes |
 
|
|
|
HuLPr46309 |
PHOSPHORYLATION |
331 |
Y |
PhosphoSitePlus |
LTP HTP |
N |
|
|
|
HuLPr46309 |
PHOSPHORYLATION |
239 |
Y |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr46309 |
PHOSPHORYLATION |
243 |
S |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr46309 |
PHOSPHORYLATION |
227 |
Y |
PhosphoSitePlus |
HTP |
N |
|
|
|
HuLPr46309 |
PHOSPHORYLATION |
19 |
S |
PhosphoSitePlus |
LTP |
yes |
|
|
|
HuLPr46309 |
PHOSPHORYLATION |
470 |
T |
PhosphoSitePlus |
HTP |
N |
|
|
|
HuLPr46309 |
PHOSPHORYLATION |
20 |
S |
PhosphoSitePlus |
HTP |
N |
|
|
|
HuLPr46309 |
PHOSPHORYLATION |
17 |
S |
PhosphoSitePlus |
HTP |
yes |
|
|
|
HuLPr46309 |
PHOSPHORYLATION |
469 |
S |
PhosphoSitePlus |
HTP |
N |
|
Pathway
| Pathway name |
