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Protein basic information

LiverAtlas Protein ID

HuLPr46385

Uniprot ID

STYX_HUMAN

Uniprot Acc

Q8WUJ0;Q99850;

Protein name

Serine/threonine/tyrosine-interacting protein

Comment

FUNCTION:Probable pseudophosphatase. Contains a Gly residue instead of a conserved Cys residue in the dsPTPase catalytic loop which renders it catalytically inactive as a phosphatase. The binding pocket is however sufficiently preserved to bind phosphorylated substrates, and maybe protect them from phosphatases. Seems to play a role in spermiogenesis (By similarity).||SUBUNIT:Interacts with CARHSP1/Crhsp-24 (By similarity).||SIMILARITY:Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.||SIMILARITY:Contains 1 tyrosine-protein phosphatase domain.

Gene name

serine/threonine/tyrosine interacting protein

Protein sequence

MEDVKLEFPSLPQCKEDAEEWTYPMRREMQEILPGLFLGP YSSAMKSKLPVLQKHGITHIICIRQNIEANFIKPNFQQL FRYLVLDIADNPVENIIRFFPMTKEFIDGSLQMGGKVLV HGNAGISRSAAFVIAYIMETFGMKYRDAFAYVQERRFCI NPNAGFVHQLQEYEAIYLAKLTIQMMSPLQIERSLSVHS GTTGSLKRTHEEEDDFGTMQVATAQNG

Database cross reference

RefSeq Protein accession:NP_001124173
RefSeq Protein gi:194733759

Liver relevance

HLPP validation

Yes/No

Yes

Project name

Human Liver Organelles;

Ontology annotation

GO-C

GO:0005737;C:cytoplasm;ISS:RefGenome.

GO-F

GO:0008138;F:protein tyrosine/serine/threonine phosphatase activity;IEA:InterPro.

GO-P

GO:0006470;P:protein dephosphorylation;IEA:InterPro. GO:0007283;P:spermatogenesis;ISS:RefGenome.