HuLPr46405

Uniprot ID

SUN2_HUMAN

Uniprot Acc

Q9UH99;O75156;Q2NKN8;Q6B4H1;Q7Z3E3;

Protein name

SUN domain-containing protein 2

Comment

FUNCTION:Component of SUN-protein-containing multivariate complexes also called LINC complexes which link the nucleoskeleton and cytoskeleton by providing versatile outer nuclear membrane attachment sites for cytoskeletal filaments. Specifically, SYNE2 and SUN2 assemble in arrays of transmembrane actin-associated nuclear (TAN) lines which are bound to F-actin cables and couple the nucleus to retrograde actin flow during actin-dependent nuclear movement. Required for interkinetic nuclear migration (INM) and essential for nucleokinesis and centrosome-nucleus coupling during radial neuronal migration in the cerebral cortex and during glial migration. Anchors chromosome movement in the prophase of meiosis and is involved in selective gene expression of coding and non-coding RNAs needed for gametogenesis. Required for telomere attachment to nuclear envelope and gametogenesis. May also function on endocytic vesicles as a receptor for RAB5-GDP and participate in the activation of RAB5.||SUBUN

Subcellular localization

Nucleus inner membrane;Single-pass type II membrane protein.Endosome membrane;Single-pass type II membrane protein(Probable).

Gene name

Sad1 and UNC84 domain containing 2

Protein sequence

MSRRSQRLTRYSQGDDDGSSSSGGSSVAGSQSTLFKDSPL RTLKRKSSNMKRLSPAPQLGPSSDAHTSYYSESLVHESW FPPRSSLEELHGDANWGEDLRVRRRRGTGGSESSRASGL VGRKATEDFLGSSSGYSSEDDYVGYSDVDQQSSSSRLRS AVSRAGSLLWMVATSPGRLFRLLYWWAGTTWYRLTTAAS LLDVFVLTRRFSSLKTFLWFLLPLLLLTCLTYGAWYFYP YGLQTFHPALVSWWAAKDSRRPDEGWEARDSSPHFQAEQ RVMSRVHSLERRLEALAAEFSSNWQKEAMRLERLELRQG APGQGGGGGLSHEDTLALLEGLVSRREAALKEDFRRETA ARIQEELSALRAEHQQDSEDLFKKIVRASQESEARIQQL KSEWQSMTQESFQESSVKELRRLEDQLAGLQQELAALAL KQSSVAEEVGLLPQQIQAVRDDVESQFPAWISQFLARGG GGRVGLLQREEMQAQLRELESKILTHVAEMQGKSAREAA ASLSLTLQKEGVIGVTEEQVHHIVKQALQRYSEDRIGLA DYALESGGASVISTRCSETYETKTALLSLFGIPLWYHSQ SPRVILQPDVHPGNCWAFQGPQGFAVVRLSARIRPTAVT LEHVPKALSPNSTISSAPKDFAIFGFDEDLQQEGTLLGK FTYDQDGEPIQTFHFQAPTMATYQVVELRILTNWGHPEYTCIYRFRVHGEPAH

Database cross reference

RefSeq Protein accession:NP_001186508
RefSeq Protein gi:313760643

HLPP validation

Yes/No

Yes

Project name

Chinese Liver;French Liver;Human Liver Organelles;

GO:0010008;C:endosome membrane;IEA:UniProtKB-SubCell. GO:0016021;C:integral to membrane;IEA:UniProtKB-KW. GO:0005637;C:nuclear inner membrane;IEA:UniProtKB-SubCell. GO:0034993;C:SUN-KASH complex;IDA:UniProtKB.

GO-F

GO:0005521;F:lamin binding;IDA:UniProtKB. GO:0008017;F:microtubule binding;TAS:UniProtKB.

GO-P

GO:0051642;P:centrosome localization;ISS:UniProtKB. GO:0090286;P:cytoskeletal anchoring at nuclear membrane;IDA:UniProtKB. GO:0007052;P:mitotic spindle organization;TAS:UniProtKB. GO:0006998;P:nuclear envelope organization;IGI:MGI. GO:0090292;P:nuclear

MOD type1

Position1

Residue1

Source name1

source ID1

Source method

HLPP validation1 (Yes/no)

Quality score

HuLPr46405

PHOSPHORYLATION

116

S

Phospho-ELM

8791

LTP

N

HuLPr46405

PHOSPHORYLATION

12

S

Phospho-ELM

8792

LTP

N

HuLPr46405

PHOSPHORYLATION

54

S

Phospho-ELM

8793

HTP

N

HuLPr46405

PHOSPHORYLATION

22

S

Phospho-ELM

11814

HTP

N

HuLPr46405

PHOSPHORYLATION

107

T

PhosphoSitePlus

478109

LTP

HTP

N

HuLPr46405

PHOSPHORYLATION

19

S

PhosphoSitePlus

4751635

HTP

N

HuLPr46405

PHOSPHORYLATION

38

S

PhosphoSitePlus

4751645

HTP

N

HuLPr46405

PHOSPHORYLATION

140

Y

PhosphoSitePlus

457191

HTP

N

HuLPr46405

PHOSPHORYLATION

143

Y

PhosphoSitePlus

457192

LTP

N

HuLPr46405

PHOSPHORYLATION

113

S

PhosphoSitePlus

3252598

LTP

N

HuLPr46405

PHOSPHORYLATION

112

S

PhosphoSitePlus

3252725

LTP

N

HuLPr46405

PHOSPHORYLATION

110

S

PhosphoSitePlus

3252885

HTP

N

HuLPr46405

PHOSPHORYLATION

124

T

PhosphoSitePlus

472445

LTP

N

HuLPr46405

PHOSPHORYLATION

12

S

PhosphoSitePlus

448844

LTP

HTP

N

HuLPr46405

PHOSPHORYLATION

54

S

PhosphoSitePlus

448845

LTP

N

HuLPr46405

PHOSPHORYLATION

116

S

PhosphoSitePlus

448846

LTP

HTP

N