Protein basic information
| LiverAtlas Protein ID |
HuLPr46426 |
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Uniprot ID |
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Uniprot Acc |
Q4FZB7;B7WNX7;Q3SX56;Q4V775;Q6P150;Q96E44;Q9BUL0;Q9H022;Q9H2K3;Q9NXV3;Q9Y393; |
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Protein name |
Histone-lysine N-methyltransferase SUV420H1 |
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Comment |
FUNCTION:Histone methyltransferase that specifically trimethylates 'Lys-20' of histone H4. H4 'Lys-20' trimethylation represents a specific tag for epigenetic transcriptional repression. Mainly functions in pericentric heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin in these regions. SUV420H1 is targeted to histone H3 via its interaction with RB1 family proteins (RB1, RBL1 and RBL2) (By similarity).||CATALYTIC ACTIVITY:S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].||SUBUNIT:Interacts with HP1 proteins CBX1, CBX3 and CBX5. Interacts with RB1 family proteins RB1, RBL1 and RBL2 (By similarity).||INTERACTION:P27348:YWHAQ; NbExp=1; IntAct=EBI-1047962, EBI-359854;||SUBCELLULAR LOCATION:Nucleus. Chromosome (By similarity). Note=Associated with pericentric heterochromatin. CBX1 and CBX5 are required for the localization to pericentric heterochromatin (By similarity).||ALTERN |
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Subcellular localization |
Nucleus.Chromosome(By similarity). |
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Gene name |
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Protein sequence
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MKWLGESKIMVVNGRRNGGKLSNDHQQNQSKLQHTGKDTL KAGKNAVERRSNRCNGNSGFEGQSRYVPSSGMSAKELCE NDDLATSLVLDPYLGFQTHKMNTSAFPSRSSRHFSKSDS FSHNNPVRFRPIKGRQEELKEVIERFKKDEHLEKAFKCL TSGEWARHYFLNKNKMQEKLFKEHVFIYLRMFATDSGFE ILPCNRYSSEQNGAKIVATKEWKRNDKIELLVGCIAELS EIEENMLLRHGENDFSVMYSTRKNCAQLWLGPAAFINHD CRPNCKFVSTGRDTACVKALRDIEPGEEISCYYGDGFFG ENNEFCECYTCERRGTGAFKSRVGLPAPAPVINSKYGLR ETDKRLNRLKKLGDSSKNSDSQSVSSNTDADTTQEKNNA TSNRKSSVGVKKNSKSRTLTRQSMSRIPASSNSTSSKLT HINNSRVPKKLKKPAKPLLSKIKLRNHCKRLEQKNASRK LEMGNLVLKEPKVVLYKNLPIKKDKEPEGPAQAAVASGC LTRHAAREHRQNPVRGAHSQGESSPCTYITRRSVRTRTN LKEASDIKLEPNTLNGYKSSVTEPCPDSGEQLQPAPVLQ EEELAHETAQKGEAKCHKSDTGMSKKKSRQGKLVKQFAK IEESTPVHDSPGKDDAVPDLMGPHSDQGEHSGTVGVPVS YTDCAPSPVGCSVVTSDSFKTKDSFRTAKSKKKRRITRY DAQLILENNSGIPKLTLRRRHDSSSKTNDQENDGMNSSK ISIKLSKDHDNDNNLYVAKLNNGFNSGSGSSSTKLKIQL KRDEENRGSYTEGLHENGVCCSDPLSLLESRMEVDDYSQ YEEESTDDSSSSEGDEEEDDYDDDFEDDFIPLPPAKRLR LIVGKDSIDIDISSRRREDQSLRLNA |
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Database cross reference |
RefSeq Protein accession:NP_057112
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Liver relevance
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HLPP validation |
Yes/No |
Yes |
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Project name |
Human Liver Organelles; |
Ontology annotation
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GO-F |
GO:0005515;F:protein binding;IPI:IntAct. |
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GO-P |
GO:0006355;P:regulation of transcription, DNA-dependent;IEA:UniProtKB-KW. GO:0006351;P:transcription, DNA-dependent;IEA:UniProtKB-KW. |
Post-translational modification
| LiverAtlas Protein ID |
MOD type1 |
Position1 |
Residue1 |
Source name1 |
source ID1 |
Source method |
HLPP validation1 (Yes/no) |
Quality score |
|
HuLPr46426 |
PHOSPHORYLATION |
307 |
Y |
PhosphoSitePlus |
LTP |
N |
 
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|
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HuLPr46426 |
PHOSPHORYLATION |
322 |
Y |
PhosphoSitePlus |
LTP |
N |
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HuLPr46426 |
PHOSPHORYLATION |
726 |
S |
PhosphoSitePlus |
LTP |
N |
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Pathway
| Pathway name |
