Protein basic information
| LiverAtlas Protein ID |
HuLPr46437 |
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Uniprot ID |
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Uniprot Acc |
Q5JTZ9;A2RRN5;Q8N198;Q96D02;Q9ULF0; |
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Protein name |
Alanyl-tRNA synthetase, mitochondrial |
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Comment |
FUNCTION:Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction:alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain (By similarity).||CATALYTIC ACTIVITY:ATP + L-alanine + tRNA(Ala) = AMP + diphosphate + L-alanyl-tRNA(Ala).||COFACTOR:Binds 1 zinc ion per subunit (Potential).||SUBUNIT:Monomer (By similarity).||SUBCELLULAR LOCATION:Mitochondrion (Potential).||DOMAIN:Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs (By similarity).||SIMILARITY:Belongs to the class-II aminoacyl-tRNA synthetase family.||SEQUENCE CAUTION:Sequence=BAA86584.1; Type=Erroneous |
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Subcellular localization |
Mitochondrion(Potential). |
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Gene name |
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Protein sequence
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MAASVAAAARRLRRAIRRSPAWRGLSHRPLSSEPPAAKAS AVRAAFLNFFRDRHGHRLVPSASVRPRGDPSLLFVNAGM NQFKPIFLGTVDPRSEMAGFRRVANSQKCVRAGGHHNDL EDVGRDLSHHTFFEMLGNWAFGGEYFKEEACNMAWELLT QVYGIPEERLWISYFDGDPKAGLDPDLETRDIWLSLGVP ASRVLSFGPQENFWEMGDTGPCGPCTEIHYDLAGGVGAP QLVELWNLVFMQHNREADGSLQPLPQRHVDTGMGLERLV AVLQGKHSTYDTDLFSPLLNAIQQGCRAPPYLGRVGVAD EGRTDTAYRVVADHIRTLSVCISDGIFPGMSGPPLVLRR ILRRAVRFSMEILKAPPGFLGSLVPVVVETLGDAYPELQ RNSAQIANLVSEDEAAFLASLERGRRIIDRTLRTLGPSD MFPAEVAWSLSLCGDLGLPLDMVELMLEEKGVQLDSAGL ERLAQEEAQHRARQAEPVQKQGLWLDVHALGELQRQGVP PTDDSPKYNYSLRPSGSYEFGTCEAQVLQLYTEDGTAVA SVGKGQRCGLLLDRTNFYAEQGGQASDRGYLVRAGQEDV LFPVARAQVCGGFILHEAVAPECLRLGDQVQLHVDEAWR LGCMAKHTATHLLNWALRQTLGPGTEQQGSHLNPEQLRL DVTTQTPLTPEQLRAVENTVQEAVGQDEAVYMEEVPLAL TAQVPGLRSLDEVYPDPVRVVSVGVPVAHALDPASQAAL QTSVELCCGTHLLRTGAVGDLVIIGDRQLSKGTTRLLAV TGEQAQQARELGQSLAQEVKAATERLSLGSRDVAEALRL SKDIGRLIEAVETAVMPQWQRRELLATVKMLQRRANTAI RKLQMGQAAKKTQELLERHSKGPLIVDTVSAESLSVLVK VVRQLCEQAPSTSVLLLSPQPMGKVLCACQVAQGAMPTF TAEAWALAVCSHMGGKAWGSRVVAQGTGSTTDLEAALSIAQTYALSQL |
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Database cross reference |
RefSeq Protein accession:NP_065796
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Liver relevance
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HLPP validation |
Yes/No |
Yes |
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Project name |
Chinese Liver;French Liver;Human Liver Organelles; |
Ontology annotation
| GO-C |
GO:0005739;C:mitochondrion;IEA:UniProtKB-SubCell. |
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GO-F |
GO:0004813;F:alanine-tRNA ligase activity;IEA:EC. GO:0005524;F:ATP binding;IEA:UniProtKB-KW. GO:0046872;F:metal ion binding;IEA:UniProtKB-KW. GO:0000049;F:tRNA binding;IEA:UniProtKB-KW. |
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GO-P |
GO:0006419;P:alanyl-tRNA aminoacylation;IEA:InterPro. |
Post-translational modification
| LiverAtlas Protein ID |
MOD type1 |
Position1 |
Residue1 |
Source name1 |
source ID1 |
Source method |
HLPP validation1 (Yes/no) |
Quality score |
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HuLPr46437 |
PHOSPHORYLATION |
712 |
S |
PhosphoSitePlus |
LTP |
N |
 
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HuLPr46437 |
PHOSPHORYLATION |
673 |
T |
PhosphoSitePlus |
LTP |
N |
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Pathway
| Pathway name |
