HuLPr46453

Uniprot ID

SYEM_HUMAN

Uniprot Acc

Q5JPH6;B3KTT2;D3DWF1;Q8TF31;

Protein name

Probable glutamyl-tRNA synthetase, mitochondrial

Comment

FUNCTION:Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction:glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity).||CATALYTIC ACTIVITY:ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu).||SUBCELLULAR LOCATION:Mitochondrion matrix (By similarity).||SIMILARITY:Belongs to the class-I aminoacyl-tRNA synthetase family.

Subcellular localization

Mitochondrion matrix(By similarity).

Gene name

glutamyl-tRNA synthetase 2, mitochondrial (putative)

Protein sequence

MAALLRRLLQRERPSAASGRPVGRREANLGTDAGVAVRVR FAPSPTGFLHLGGLRTALYNYIFAKKYQGSFILRLEDTD QTRVVPGAAENIEDMLEWAGIPPDESPRRGGPAGPYQQS QRLELYAQATEALLKTGAAYPCFCSPQRLELLKKEALRN HQTPRYDNRCRNMSQEQVAQKLAKDPKPAIRFRLEQVVP AFQDLVYGWNRHEVASVEGDPVIMKSDGFPTYHLACVVD DHHMGISHVLRGSEWLVSTAKHLLLYQALGWQPPHFAHL PLLLNRDGSKLSKRQGDVFLEHFAADGFLPDSLLDIITN CGSGFAENQMGRTLPELITQFNLTQVTCHSALLDLEKLP EFNRLHLQRLVSNESQRRQLVGKLQVLVEEAFGCQLQNR DVLNPVYVERILLLRQGHICRLQDLVSPVYSYLWTRPAV GRAQLDAISEKVDVIAKRVLGLLERSSMSLTQDMLNGEL KKLSEGLEGTKYSNVMKLLRMALSGQQQGPPVAEMMLAL GPKEVRERIQKVVSS

Database cross reference

RefSeq Protein accession:NP_001077083
RefSeq Protein gi:134288884

HLPP validation

Yes/No

Yes

Project name

Human Liver Organelles;

GO:0005759;C:mitochondrial matrix;IEA:UniProtKB-SubCell.

GO-F

GO:0005524;F:ATP binding;IEA:UniProtKB-KW. GO:0004818;F:glutamate-tRNA ligase activity;IEA:EC. GO:0003723;F:RNA binding;IEA:UniProtKB-KW.

GO-P

GO:0006424;P:glutamyl-tRNA aminoacylation;IEA:InterPro.

MOD type1

Position1

Residue1

Source name1

source ID1

Source method

HLPP validation1 (Yes/no)

Quality score

HuLPr46453

PHOSPHORYLATION

46

T

PhosphoSitePlus

18009147

LTP

N

HuLPr46453

ACETYLATION

486

K

PhosphoSitePlus

11321586

HTP

N

Glutamate_Metabolism