HuLPr46463

Uniprot ID

SYHM_HUMAN

Uniprot Acc

P49590;

Protein name

Probable histidyl-tRNA synthetase, mitochondrial

Comment

CATALYTIC ACTIVITY:ATP + L-histidine + tRNA(His) = AMP + diphosphate + L-histidyl-tRNA(His).||SUBCELLULAR LOCATION:Mitochondrion matrix (By similarity).||TISSUE SPECIFICITY:A high level expression is seen in the heart, kidney and skeletal muscle while a lower level expression is seen in the brain and liver.||SIMILARITY:Belongs to the class-II aminoacyl-tRNA synthetase family.

Subcellular localization

Mitochondrion matrix(By similarity).

Gene name

histidyl-tRNA synthetase 2, mitochondrial (putative)

Protein sequence

MPLLGLLPRRAWASLLSQLLRPPCASCTGAVRCQSQVAEA VLTSQLKAHQEKPNFIIKTPKGTRDLSPQHMVVREKILD LVISCFKRHGAKGMDTPAFELKETLTEKYGEDSGLMYDL KDQGGELLSLRYDLTVPFARYLAMNKVKKMKRYHVGKVW RRESPTIVQGRYREFCQCDFDIAGQFDPMIPDAECLKIM CEILSGLQLGDFLIKVNDRRIVDGMFAVCGVPESKFRAI CSSIDKLDKMAWKDVRHEMVVKKGLAPEVADRIGDYVQC HGGVSLVEQMFQDPRLSQNKQALEGLGDLKLLFEYLTLF GIADKISFDLSLARGLDYYTGVIYEAVLLQTPTQAGEEP LNVGSVAAGGRYDGLVGMFDPKGHKVPCVGLSIGVERIF YIVEQRMKTKGEKVRTTETQVFVATPQKNFLQERLKLIA ELWDSGIKAEMLYKNNPKLLTQLHYCESTGIPLVVIIGE QELKEGVIKIRSVASREEVAIKRENFVAEIQKRLSES

Database cross reference

RefSeq Protein accession:NP_036340
RefSeq Protein gi:15029520

GO:0005759;C:mitochondrial matrix;EXP:Reactome.

GO-F

GO:0005524;F:ATP binding;NAS:UniProtKB. GO:0004821;F:histidine-tRNA ligase activity;NAS:UniProtKB.

GO-P

GO:0006427;P:histidyl-tRNA aminoacylation;IEA:InterPro.

MOD type1

Position1

Residue1

Source name1

source ID1

Source method

HLPP validation1 (Yes/no)

Quality score

HuLPr46463

PHOSPHORYLATION

67

S

Phospho-ELM

12310

HTP

N

HuLPr46463

PHOSPHORYLATION

364

Y

PhosphoSitePlus

18010303

LTP

N

HuLPr46463

ACETYLATION

444

K

PhosphoSitePlus

11320753

HTP

N

HuLPr46463

PHOSPHORYLATION

67

S

PhosphoSitePlus

470423

LTP

HTP

N

HuLPr46463

ACETYLATION

419

K

PhosphoSitePlus

475585

HTP

N

Histidine_Metabolism