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Protein basic information

LiverAtlas Protein ID

HuLPr46471

Uniprot ID

SYMM_HUMAN

Uniprot Acc

Q96GW9;A0AVC3;Q76E79;Q8IW62;Q8N7N4;

Protein name

Methionyl-tRNA synthetase, mitochondrial

Comment

CATALYTIC ACTIVITY:ATP + L-methionine + tRNA(Met) = AMP + diphosphate + L-methionyl-tRNA(Met).||BIOPHYSICOCHEMICAL PROPERTIES:Kinetic parameters: KM=18 uM for Met; KM=85 uM for ATP; KM=2.1 uM for tRNA-Met; pH dependence: Optimum pH is 7.8-8.2;||SUBCELLULAR LOCATION:Mitochondrion matrix (Probable).||SIMILARITY:Belongs to the class-I aminoacyl-tRNA synthetase family.||SEQUENCE CAUTION:Sequence=AAH09115.1; Type=Erroneous initiation; Sequence=AAH40934.1; Type=Erroneous initiation;

Subcellular localization

Mitochondrion matrix(Probable).

Gene name

methionyl-tRNA synthetase 2, mitochondrial

Protein sequence

MLRTSVLRLLGRTGASRLSLLEDFGPRYYSSGSLSAGDDA CDVRAYFTTPIFYVNAAPHIGHLYSALLADALCRHRRLR GPSTAATRFSTGTDEHGLKIQQAAATAGLAPTELCDRVS EQFQQLFQEAGISCTDFIRTTEARHRVAVQHFWGVLKSR GLLYKGVYEGWYCASDECFLPEAKVTQQPGPSGDSFPVS LESGHPVSWTKEENYIFRLSQFRKPLQRWLRGNPQAITP EPFHHVVLQWLDEELPDLSVSRRSSHLHWGIPVPGDDSQ TIYVWLDALVNYLTVIGYPNAEFKSWWPATSHIIGKDIL KFHAIYWPAFLLGAGMSPPQRICVHSHWTVCGQKMSKSL GNVVDPRTCLNRYTVDGFRYFLLRQGVPNWDCDYYDEKV VKLLNSELADALGGLLNRCTAKRINPSETYPAFCTTCFP SEPGLVGPSVRAQAEDYALVSAVATLPKQVADHYDNFRI YKALEAVSSCVRQTNGFVQRHAPWKLNWESPVDAPWLGT VLHVALECLRVFGTLLQPVTPSLADKLLSRLGVSASERS LGELYFLPRFYGHPCPFEGRRLGPETGLLFPRLDQSRTWLVKAHRT

Database cross reference

RefSeq Protein accession:NP_612404
RefSeq Protein gi:24308436

Liver relevance

HLPP validation

Yes/No

Yes

Project name

Chinese Liver;Human Liver Organelles;

Ontology annotation

GO-C

GO:0005759;C:mitochondrial matrix;IDA:UniProtKB.

GO-F

GO:0005524;F:ATP binding;IEA:UniProtKB-KW. GO:0004825;F:methionine-tRNA ligase activity;IDA:UniProtKB.

GO-P

GO:0006431;P:methionyl-tRNA aminoacylation;IDA:UniProtKB.