HuLPr46515

Uniprot ID

SYTL2_HUMAN

Uniprot Acc

Q9HCH5;B3KRS3;B4DJT5;B4DKW3;B4DQ26;B7SA85;B7ZLX6;B7ZLX7;Q2YDA7;Q6TV07;Q6ZN59;Q6ZVC5;Q8ND34;Q96BJ2;Q9H768;Q9NXM1;

Protein name

Synaptotagmin-like protein 2

Comment

FUNCTION:Isoform 1 acts as a RAB27A effector protein and plays a role in cytotoxic granule exocytosis in lymphocytes. It is required for cytotoxic granule docking at the immunologic synapse. Isoform 4 binds phosphatidylserine (PS) and phosphatidylinositol- 4,5-bisphosphate (PIP2) and promotes the recruitment of glucagon- containing granules to the cell membrane in pancreatic alpha cells. Binding to PS is inhibited by Ca(2+) while binding to PIP2 is Ca(2+) insensitive.||SUBUNIT:Monomer. Binds NRXN1. Interacts with RAB27B (By similarity). Binds RAB27A that has been activated by GTP-binding.||SUBCELLULAR LOCATION:Isoform 1:Cytoplasm. Cell membrane. Note=Recruited on vesicular structures in cytotoxic T-lymphocytes (CTL) by RAB27A.||SUBCELLULAR LOCATION:Isoform 4:Cell membrane. Note=In the pancreatic alpha cells distributed in both peripheral and anterior regions. Localizes on the glucagon granules in the cell periphery.||ALTERNATIVE PRODUCTS:Event=Alternative splicing; Named isoforms=12; N

Subcellular localization

Isoform 1:Cytoplasm.Cell membrane.

Gene name

synaptotagmin-like 2

Protein sequence

MIDLSFLTEEEQEAIMKVLQRDAALKRAEEERVRHLPEKI KDDQQLKNMSGQWFYEAKAKRHRDKIHGADIIRASMRKK RPQIAAEQSKDRENGAKESWVNNVNKDAFLPPELAGVVE EPEEDAAPASPSSSVVNPASSVIDMSQENTRKPNVSPEK RKNPFNSSKLPEGHSSQQTKNEQSKNGRTGLFQTSKEDE LSESKEKSTVADTSIQKLEKSKQTLPGLSNGSQIKAPIP KARKMIYKSTDLNKDDNQSFPRQRTDSLKARGAPRGILK RNSSSSSTDSETLRYNHNFEPKSKIVSPGLTIHERISEK EHSLEDNSSPNSLEPLKHVRFSAVKDELPQSPGLIHGRE VGEFSVLESDRLKNGMEDAGDTEEFQSDPKPSQYRKPSL FHQSTSSPYVSKSETHQPMTSGSFPINGLHSHSEVLTAR PQSMENSPTINEPKDKSSELTRLESVLPRSPADELSHCV EPEPSQVPGGSSRDRQQGSEEEPSPVLKTLERSAARKMP SKSLEDISSDSSNQAKVDNQPEELVRSAEDVSTVPTQPD NPFSHPDKLKRMSKSVPAFLQDESDDRETDTASESSYQL SRHKKSPSSLTNLSSSSGMTSLSSVSGSVMSVYSGDFGN LEVKGNIQFAIEYVESLKELHVFVAQCKDLAAADVKKQR SDPYVKAYLLPDKGKMGKKKTLVVKKTLNPVYNEILRYK IEKQILKTQKLNLSIWHRDTFKRNSFLGEVELDLETWDW DNKQNKQLRWYPLKRKTAPVALEAENRGEMKLALQYVPE PVPGKKLPTTGEVHIWVKECLDLPLLRGSHLNSFVKCTI LPDTSRKSRQKTRAVGKTTNPIFNHTMVYDGFRPEDLME ACVELTVWDHYKLTNQFLGGLRIGFGTGKSYGTEVDWMD STSEEVALWEKMVNSPNTWIEATLPLRMLLIAKISK

Database cross reference

RefSeq Protein accession:NP_001156423
RefSeq Protein gi:244790013

HLPP validation

Yes/No

Yes

Project name

Human Liver Organelles;

GO:0070382;C:exocytic vesicle;IDA:UniProtKB. GO:0019897;C:extrinsic to plasma membrane;ISS:UniProtKB. GO:0042470;C:melanosome;ISS:UniProtKB. GO:0005624;C:membrane fraction;ISS:UniProtKB.

GO-F

GO:0042043;F:neurexin binding;ISS:UniProtKB. GO:0005546;F:phosphatidylinositol-4,5-bisphosphate binding;IMP:UniProtKB. GO:0001786;F:phosphatidylserine binding;IMP:UniProtKB. GO:0017137;F:Rab GTPase binding;IEA:InterPro. GO:0008270;F:zinc ion binding;IE

GO-P

GO:0006886;P:intracellular protein transport;IEA:InterPro. GO:0006904;P:vesicle docking involved in exocytosis;IDA:UniProtKB.

MOD type1

Position1

Residue1

Source name1

source ID1

Source method

HLPP validation1 (Yes/no)

Quality score

HuLPr46515

PHOSPHORYLATION

385

Y

PhosphoSitePlus

474107

HTP

N