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Protein basic information

LiverAtlas Protein ID

HuLPr46554

Uniprot ID

T176B_HUMAN

Uniprot Acc

Q3YBM2;B2RDK2;D3DWZ7;Q5BJI2;Q9BT42;Q9Y609;

Protein name

Transmembrane protein 176B

Comment

FUNCTION:May play a role in the process of maturation of dendritic cells. Required for the development of cerebellar granule cells (By similarity).||SUBCELLULAR LOCATION:Nucleus membrane; Multi-pass membrane protein (By similarity).||TISSUE SPECIFICITY:Expressed in lung and dermal fibroblasts.||INDUCTION:Up-regulated in fibrotic lung. Down-regulated in activated dendritic cells.||SIMILARITY:Belongs to the TMEM176 family.||SEQUENCE CAUTION:Sequence=AAH91471.1; Type=Erroneous termination; Positions=30; Note=Translated as Glu;

Subcellular localization

Nucleus membrane;Multi-pass membrane protein(By similarity).

Gene name

transmembrane protein 176B

Protein sequence

MTQNTVIVNGVAMASRPSQPTHVNVHIHQESALTQLLKAG GSLKKFLFHPGDTVPSTARIGYEQLALGVTQILLGVVSC VLGVCLSLGPWTVLSASGCAFWAGSVVIAAGAGAIVHEK HPGKLAGYISSLLTLAGFATAMAAVVLCVNSFIWQTEPF LYIDTVCDRSDPVFPTTGYRWMRRSQENQWQKEECRAYM QMLRKLFTAIRALFLAVCVLKVIVSLVSLGVGLRNLCGQ SSQPLNEEGSEKRLLGENSVPPSPSREQTSTAIVL

Database cross reference

RefSeq Protein accession:NP_001094781
RefSeq Protein gi:156416016

Liver relevance

HLPP validation

Yes/No

Yes

Project name

Chinese Liver;Human Liver Organelles;

Ontology annotation

GO-C

GO:0016021;C:integral to membrane;IEA:UniProtKB-KW. GO:0031965;C:nuclear membrane;IEA:UniProtKB-SubCell.

GO-P

GO:0030154;P:cell differentiation;IEA:UniProtKB-KW. GO:0009887;P:organ morphogenesis;TAS:ProtInc.