Choose one of the five choices you want to search:

Gene, Transcriptome, Protein, Pathway or Disease. 

Protein basic information

LiverAtlas Protein ID

HuLPr46602

Uniprot ID

T53I1_HUMAN

Uniprot Acc

Q96A56;B2RCE5;Q969R9;

Protein name

Tumor protein p53-inducible nuclear protein 1

Comment

FUNCTION:In response to double-strand DNA breaks, promotes p53/TP53 phosphorylation on 'Ser-46' and subsequent apoptosis.||SUBUNIT:Interacts with TP53 and HIPK2.||SUBCELLULAR LOCATION:Nucleus, PML body.||ALTERNATIVE PRODUCTS:Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=p53DINP1a, alpha, SIP27, TEAP; IsoId=Q96A56-1; Sequence=Displayed; Name=2; Synonyms=p53DINP1b, beta, SIP18; IsoId=Q96A56-2; Sequence=VSP 013176;||TISSUE SPECIFICITY:Ubiquitously expressed.||INDUCTION:By adriamycin, gamma irradiation and H(2)O(2), in a p53/TP53-dependent way. At lower levels by UV irradiation.

Subcellular localization

Nucleus, PML body.

Gene name

tumor protein p53 inducible nuclear protein 1

Protein sequence

MFQRLNKMFVGEVSSSSNQEPEFNEKEDDEWILVDFIDTC TGFSAEEEEEEEDISEESPTEHPSVFSCLPASLECLADT SDSCFLQFESCPMEESWFITPPPCFTAGGLTTIKVETSP MENLLIEHPSMSVYAVHNSCPGLSEATRGTDELHSPSSP RVEAQNEMGQHIHCYVAALAAHTTFLEQPKSFRPSQWIK EHSERQPLNRNSLRRQNLTRDCHPRQVKHNGWVVHQPCP RQYNY

Database cross reference

RefSeq Protein accession:NP_001129205
RefSeq Protein gi:209180469

Liver relevance

HLPP validation

Yes/No

Yes

Project name

Human Liver Organelles;

Ontology annotation

GO-C

GO:0016605;C:PML body;IEA:UniProtKB-SubCell.

GO-P

GO:0006915;P:apoptosis;IEA:UniProtKB-KW.

Pathway

Pathway name

Direct_p53_effectors