Protein basic information
| LiverAtlas Protein ID |
HuLPr46637 |
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Uniprot ID |
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Uniprot Acc |
Q15572;B7Z5K5;B7Z5S4;B7Z908;B7Z9L7;Q59F67;Q8N6V3; |
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Protein name |
TATA box-binding protein-associated factor RNA polymerase I subunit C |
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Comment |
FUNCTION:Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC (preinitiation complex) during RNA polymerase I-dependent transcription. The rate of PIC formation probably is primarily dependent on the rate of association of SL1/TIF-IB with the rDNA promoter. SL1/TIF-IB is involved in stabilization of nucleolar transcription factor 1/UBTF on rDNA. Formation of SL1/TIF-IB excludes the association of TBP with TFIID subunits. Recruits RNA polymerase I to the rRNA gene promoter via interaction with RRN3.||SUBUNIT:Component of the transcription factor SL1/TIF-IB complex, composed of TBP and at least TAF1A, TAF1B, TAF1C and TAF1D. In the complex interacts directly with TBP, TAF1A and TAF1B. Interaction of the SL1/TIF-IB subunits with TBP excludes interaction of TBP with the transcription factor IID (TFIID) subunits. Interacts with MYC and RRN3. Interacts with p53/TP53; the interaction prevents the association of SL1/TIF-IB with UBTF and repress |
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Subcellular localization |
Nucleus. |
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Gene name |
TATA box binding protein (TBP)-associated factor, RNA polymerase I, C, 110kDa |
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Related liver disease name |
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Protein sequence
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MDFPSSLRPALFLTGPLGLSDVPDLSFMCSWRDALTLPEA QPQNSENGALHVTKDLLWEPATPGPLPMLPPLIDPWDPG LTARDLLFRGGCRYRKRPRVVLDVTEQISRFLLDHGDVA FAPLGKLMLENFKLEGAGSRTKKKTVVSVKKLLQDLGGH QPWGCPWAYLSNRQRRFSILGGPILGTSVASHLAELLHE ELVLRWEQLLLDEACTGGALAWVPGRTPQFGQLVYPAGG AQDRLHFQEVVLTPGDNPQFLGKPGRIQLQGPVRQVVTC TVQGESKALIYTFLPHWLTCYLTPGPFHPSSALLAVRSD YHCAVWKFGKQWQPTLLQAMQVEKGATGISLSPHLPGEL AICSRSGAVCLWSPEDGLRQIYRDPETLVFRDSSSWRWA DFTAHPRVLTVGDRTGVKMLDTQGPPGCGLLLFRLGAEA SCQKGERVLLTQYLGHSSPKCLPPTLHLVCTQFSLYLVD ERLPLVPMLKWNHGLPSPLLLARLLPPPRPSCVQPLLLG GQGGQLQLLHLAGEGASVPRLAGPPQSLPSRIDSLPAFP LLEPKIQWRLQERLKAPTIGLAAVVPPLPSAPTPGLVLF QLSAAGDVFYQQLRPQVDSSLRRDAGPPGDTQPDCHAPT ASWTSQDTAGCSQWLKALLKVPLAPPVWTAPTFTHRQML GSTELRREEEEGQRLGVLRKAMARGQLLLQRDLGSLPAA EPPPAPESGLEDKLSERLGEAWAGRGAAWWERQQGRTSE PGRQTRRPKRRTQLSSSFSLSGHVDPSEDTSSPHSPEWP PADALPLPPTTPPSQELTPDACAQGVPSEQRQMLRDYMA KLPPQRDTPGCATTPPHSQASSVRATRSQQHTPVLSSSQPLRKKPRMGF |
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Database cross reference |
RefSeq Protein accession:NP_005670
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Liver relevance
| Liver sepcificity |
Yes/No |
Yes |
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Evidence |
BodyMap |
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Quality score |
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HCC significant Proteins |
Yes/No |
Yes |
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Quality score |
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Ontology annotation
| GO-C |
GO:0005654;C:nucleoplasm;EXP:Reactome. |
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GO-F |
GO:0003677;F:DNA binding;IEA:UniProtKB-KW. GO:0016251;F:general RNA polymerase II transcription factor activity;TAS:ProtInc. GO:0003701;F:RNA polymerase I transcription factor activity;TAS:ProtInc. |
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GO-P |