HuLPr46659

Uniprot ID

TALAN_HUMAN

Uniprot Acc

Q70YC4;

Protein name

Talanin

Comment

FUNCTION:May play a role in uric acid excretion.||ALTERNATIVE PRODUCTS:Event=Alternative splicing; Named isoforms=6; Comment=Additional isoforms seem to exist; Name=4; Synonyms=Talanin, ZNF365D; IsoId=Q70YC4-1; Sequence=Displayed; Name=1; Synonyms=ZNF365A; IsoId=Q70YC5-1; Sequence=External; Name=2; Synonyms=ZNF365B; IsoId=Q70YC5-2; Sequence=External; Name=3; Synonyms=ZNF365C; IsoId=Q70YC5-3; Sequence=External; Name=5; IsoId=Q70YC5-4; Sequence=External; Note=No experimental confirmation available; Name=6; IsoId=Q70YC5-5; Sequence=External; Note=No experimental confirmation available;||TISSUE SPECIFICITY:Isoform 4 is expressed in placenta, lung, kidney and pancreas.||POLYMORPHISM:Thr-62 is associated with increased risk for uric acid nephrolithiasis.||DISEASE:Genetic variation in ZNF365 is a cause of susceptibility to uric acid nephrolithiasis (UAN) [MIM:605990]. UAN occurs when the urine becomes overly concentrated with uric acid that may form small crystals.||MISCELLA

Gene name

zinc finger protein 365

Protein sequence

MSALGQITITVSRCWNTERNQTDKNPCLHGAYLQLRETVK NKSTHLKKPLMKQAPPWKDHLTFQPLHPAERKTQVWRWQ SGNSSDLETTSSASPWPTGSNRDVVLNTLAESCCGLSEL ITAPPYAGVSIQGFSQIWVLFPFCGGTFHHNEKDVLGLQ DFERESVSTSQSRNISLLTLGQLQNCVIGKLTIIDLLTE HLLGVRHGVICFPWGLPSSS

Database cross reference

RefSeq Protein accession:NP_055766
RefSeq Protein gi:148596972

HLPP validation

Yes/No

Yes

Project name

Chinese Liver;