HuLPr46666

Uniprot ID

TAOK3_HUMAN

Uniprot Acc

Q9H2K8;Q658N1;Q8IUM4;Q9HC79;Q9NZM9;Q9UHG7;

Protein name

Serine/threonine-protein kinase TAO3

Comment

FUNCTION:Inhibits the basal activity of Jun kinase. Negatively regulated by epidermal growth factor (EGF). When overexpressed, may activate ERK1/ERK2 and JNK/SAPK.||CATALYTIC ACTIVITY:ATP + a protein = ADP + a phosphoprotein.||SUBUNIT:Self-associates. Interacts with ERN1 and TRAF2. Interaction with TRAF2 is facilitated under ER stress conditions, such as treatment with tunicamycin, and may promote TRAF2 phosphorylation.||SUBCELLULAR LOCATION:Cytoplasm. Cell membrane; Peripheral membrane protein. Note=Also localized to the peripheral cell membrane.||TISSUE SPECIFICITY:Ubiquitously expressed at a low level, and highly expressed in peripheral blood leukocytes (PBLs), thymus, spleen, kidney, skeletal muscle, heart and liver.||PTM:Autophosphorylated. Phosphorylated upon DNA damage, probably by ATM or ATR.||SIMILARITY:Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.||SIMILARITY:Contains 1 protein kinase domain.||SEQUENCE CAUTION:Sequence=AAN09723

Subcellular localization

Cytoplasm.Cell membrane;Peripheral membrane protein.

Gene name

TAO kinase 3

Protein sequence

MRKGVLKDPEIADLFYKDDPEELFIGLHEIGHGSFGAVYF ATNAHTSEVVAIKKMSYSGKQTHEKWQDILKEVKFLRQL KHPNTIEYKGCYLKEHTAWLVMEYCLGSASDLLEVHKKP LQEVEIAAITHGALHGLAYLHSHALIHRDIKAGNILLTE PGQVKLADFGSASMASPANSFVGTPYWMAPEVILAMDEG QYDGKVDIWSLGITCIELAERKPPLFNMNAMSALYHIAQ NDSPTLQSNEWTDSFRRFVDYCLQKIPQERPTSAELLRH DFVRRDRPLRVLIDLIQRTKDAVRELDNLQYRKMKKILF QETRNGPLNESQEDEEDSEHGTSLNREMDSLGSNHSIPS MSVSTGSQSSSVNSMQEVMDESSSELVMMHDDESTINSS SSVVHKKDHVFIRDEAGHGDPRPEPRPTQSVQSQALHYR NRERFATIKSASLVTRQIHEHEQENELREQMSGYKRMRR QHQKQLIALENKLKAEMDEHRLKLQKEVETHANNSSIEL EKLAKKQVAIIEKEAKVAAADEKKFQQQILAQQKKDLTT FLESQKKQYKICKEKIKEEMNEDHSTPKKEKQERISKHK ENLQHTQAEEEAHLLTQQRLYYDKNCRFFKRKIMIKRHE VEQQNIREELNKKRTQKEMEHAMLIRHDESTRELEYRQL HTLQKLRMDLIRLQHQTELENQLEYNKRRERELHRKHVM ELRQQPKNLKAMEMQIKKQFQDTCKVQTKQYKALKNHQL EVTPKNEHKTILKTLKDEQTRKLAILAEQYEQSINEMMA SQALRLDEAQEAECQALRLQLQQEMELLNAYQSKIKMQT EAQHERELQKLEQRVSLRRAHLEQKIEEELAALQKERSE RIKNLLERQEREIETFDMESLRMGFGNLVTLDFPKEDYR

Database cross reference

RefSeq Protein accession:NP_057365
RefSeq Protein gi:148746218

HLPP validation

Yes/No

Yes

Project name

Chinese Liver;French Liver;Human Liver Organelles;

GO:0005739;C:mitochondrion;IDA:HPA. GO:0005886;C:plasma membrane;IEA:UniProtKB-SubCell.

GO-F

GO:0005524;F:ATP binding;IEA:UniProtKB-KW. GO:0004860;F:protein kinase inhibitor activity;TAS:ProtInc. GO:0004674;F:protein serine/threonine kinase activity;IDA:HGNC.

GO-P

GO:0000165;P:MAPKKK cascade;IMP:HGNC. GO:0046329;P:negative regulation of JNK cascade;IDA:HGNC. GO:0046330;P:positive regulation of JNK cascade;IMP:HGNC. GO:0046777;P:protein autophosphorylation;IDA:HGNC.

MOD type1

Position1

Residue1

Source name1

source ID1

Source method

HLPP validation1 (Yes/no)

Quality score

HuLPr46666

PHOSPHORYLATION

324

S

Phospho-ELM

20219

HTP

N

HuLPr46666

PHOSPHORYLATION

331

S

Phospho-ELM

20220

HTP

N

HuLPr46666

PHOSPHORYLATION

442

S

Phospho-ELM

39011

HTP

yes

HuLPr46666

PHOSPHORYLATION

331

S

PhosphoSitePlus

482200

LTP

N

HuLPr46666

PHOSPHORYLATION

177

S

PhosphoSitePlus

7322716

LTP

HTP

N

HuLPr46666

PHOSPHORYLATION

103

Y

PhosphoSitePlus

3974159

LTP

N

HuLPr46666

PHOSPHORYLATION

551

S

PhosphoSitePlus

11952936

LTP

HTP

N

HuLPr46666

PHOSPHORYLATION

316

T

PhosphoSitePlus

7447079

HTP

N

HuLPr46666

PHOSPHORYLATION

305

Y

PhosphoSitePlus

1037867

LTP

N

HuLPr46666

PHOSPHORYLATION

324

S

PhosphoSitePlus

468901

LTP

HTP

N

HuLPr46666

PHOSPHORYLATION

359

S

PhosphoSitePlus

468905

LTP

N

HuLPr46666

PHOSPHORYLATION

442

S

PhosphoSitePlus

468906

HTP

yes

p38_MAPK_signaling_pathway

EGF/MAPK