Protein basic information
| LiverAtlas Protein ID |
HuLPr46672 |
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Uniprot ID |
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Uniprot Acc |
Q13395;Q9H581; |
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Protein name |
Probable methyltransferase TARBP1 |
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Comment |
FUNCTION:Probable S-adenosyl-L-methionine-dependent methyltransferase which methylates RNA molecules such as tRNAs. In case of infection by HIV-1, it binds to the loop region of TAR RNA, a region also bound by RNA polymerase II. Binding of TARBP1 and RNA polymerase II to HIV-1 TAR RNA is mutually exclusive, suggesting that TARBP1 may function alone or in conjunction with HIV-1 Tat to disengage RNA polymerase II from HIV-1 TAR RNA. May act by methylating HIV-1 TAR RNA.||SUBUNIT:Monomer and homodimer.||SIMILARITY:Belongs to the RNA methyltransferase TrmH family. |
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Gene name |
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Protein sequence
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MEWVLAEALLSQSRDPRALLGALCQGEASAERVETLRFLL QRLEDEEARGSGGAGALPEAAREVAAGYLVPLLRSLRGR PAGGPDPSLQPRHRRRVLRAAGAALRSCVRLAGRPQLAA ALAEEALRDLLAGWRAPGAEAAVEVLAAVGPCLRPREDG PLLERVAGTAVALALGGGGDGDEAGPAEDAAALVAGRLL PVLVQCGGAALRAVWGGLAAPGASLGSGRVEEKLLVLSA LAEKLLPEPGGDRARGAREAGPDARRCWRFWRTVQAGLG QADALTRKRARYLLQRAVEVSAELGADCTCGPQEGNGPS LFWWSERKKDELLKFWENYILIMETLEGNQIHVIKPVLP KLNNLFEYAVSEENGCWLFHPSWHMCIYKRMFESENKIL SKEGVIHFLELYETKILPFSPEFSEFIIGPLMDALSESS LYSRSPGQPIGSCSPLGLKLQKFLVTYISLLPEEIKSSF LLKFIRKMTSRHWCAVPILFLSKALANVPRHKALGIDGL LALRDVIHCTMITHQILLRGAAQCYLLQTAMNLLDVEKV SLSDVSTFLMSLRQEESLGRGTSLWTELCDWLRVNESYF KPSPTCSSIGLHKTSLNAYVKSIVQEYVKSSAWETGENC FMPDWFEAKLVSLMVLLAVDVEGMKTQYSGKQRTENVLR IFLDPLLDVLMKFSTNAYMPLLKTDRCLQLLLKLLNTCR LKGSSAQDDEVSTVLQNFFMSTTESISEFILRRLTMNEL NSVSDLDRCHLYLMVLTELINLHLKVGWKRGNPIWRVIS LLKNASIQHLQEMDSGQEPTVGSQIQRVVSMAALAMVCE AIDQKPELQLDSLHAGPLESFLSSLQLNQTLQKPHAEEQ SSYAHPLECSSVLEESSSSQGWGKIVAQYIHDQWVCLSF LLKKYHTLIPTTGSEILEPFLPAVQMPIRTLQSALEALT VLSSDQVLPVFHCLKVLVPKLLTSSESLCIESFDMAWKI ISSLSNTQLIFWANLKAFVQFVFD |
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Database cross reference |
RefSeq Protein accession:NP_005637
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Liver relevance
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HLPP validation |
Yes/No |
Yes |
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Project name |
Chinese Liver;Human Fetal Liver;Human Liver Organelles; |
Ontology annotation
| GO-C |
GO:0005634;C:nucleus;TAS:ProtInc. |
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GO-F |
GO:0003723;F:RNA binding;TAS:ProtInc. GO:0008173;F:RNA methyltransferase activity;IEA:InterPro. |
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GO-P |
GO:0006357;P:regulation of transcription from RNA polymerase II promoter;TAS:ProtInc. GO:0006396;P:RNA processing;IEA:InterPro. |
Post-translational modification
| LiverAtlas Protein ID |
MOD type1 |
Position1 |
Residue1 |
Source name1 |
source ID1 |
Source method |
HLPP validation1 (Yes/no) |
Quality score |
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HuLPr46672 |
PHOSPHORYLATION |
1289 |
Y |
PhosphoSitePlus |
LTP |
N |
 
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HuLPr46672 |
PHOSPHORYLATION |
1442 |
S |
PhosphoSitePlus |
LTP |
N |
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