Protein basic information
| LiverAtlas Protein ID |
HuLPr46788 |
|
Uniprot ID |
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Uniprot Acc |
O75764; |
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Protein name |
Transcription elongation factor A protein 3 |
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Comment |
FUNCTION:Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3'-terminus.||SUBCELLULAR LOCATION:Nucleus (By similarity).||SIMILARITY:Belongs to the TFS-II family.||SIMILARITY:Contains 1 TFIIS central domain.||SIMILARITY:Contains 1 TFIIS N-terminal domain.||SIMILARITY:Contains 1 TFIIS-type zinc finger. |
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Subcellular localization |
Nucleus(By similarity). |
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Gene name |
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Protein sequence
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MGQEEELLRIAKKLEKMVARKNTEGALDLLKKLHSCQMSI QLLQTTRIGVAVNGVRKHCSDKEVVSLAKVLIKNWKRLL DSPGPPKGEKGEEREKAKKKEKGLECSDWKPEAGLSPPR KKREDPKTRRDSVDSKSSASSSPKRPSVERSNSSKSKAE SPKTPSSPLTPTFASSMCLLAPCYLTGDSVRDKCVEMLS AALKADDDYKDYGVNCDKMASEIEDHIYQELKSTDMKYR NRVRSRISNLKDPRNPGLRRNVLSGAISAGLIAKMTAEE MASDELRELRNAMTQEAIREHQMAKTGGTTTDLFQCSKC KKKNCTYNQVQTRSADEPMTTFVLCNECGNRWKFC |
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Database cross reference |
RefSeq Protein accession:NP_003187
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Liver relevance
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HLPP validation |
Yes/No |
Yes |
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Project name |
Chinese Liver;French Liver;Human Liver Organelles; |
Ontology annotation
| GO-C |
GO:0005634;C:nucleus;IEA:UniProtKB-SubCell. |
|
GO-F |
GO:0003677;F:DNA binding;IEA:UniProtKB-KW. GO:0003702;F:RNA polymerase II transcription factor activity;IEA:InterPro. GO:0003711;F:transcription elongation regulator activity;IEA:InterPro. GO:0003746;F:translation elongation factor activity;IEA:InterPro |
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GO-P |
GO:0006357;P:regulation of transcription from RNA polymerase II promoter;IEA:InterPro. GO:0006354;P:transcription elongation, DNA-dependent;IEA:InterPro. |
Post-translational modification
| LiverAtlas Protein ID |
MOD type1 |
Position1 |
Residue1 |
Source name1 |
source ID1 |
Source method |
HLPP validation1 (Yes/no) |
Quality score |
|
HuLPr46788 |
PHOSPHORYLATION |
115 |
S |
PhosphoSitePlus |
HTP |
yes |
 
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