HuLPr46846

Uniprot ID

TECR_HUMAN

Uniprot Acc

Q9NZ01;B2RD55;O75350;Q6IBB2;Q9BWK3;Q9Y6P0;

Protein name

Trans-2,3-enoyl-CoA reductase

Comment

FUNCTION:Reduces trans-2,3-stearoyl-CoA to stearoyl-CoA of long and very long chain fatty acids.||CATALYTIC ACTIVITY:Acyl-CoA + NADP(+) = trans-2,3-dehydroacyl-CoA + NADPH.||SUBUNIT:Interacts with ELOVL1 and LASS2.||SUBCELLULAR LOCATION:Endoplasmic reticulum membrane; Multi-pass membrane protein.||ALTERNATIVE PRODUCTS:Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9NZ01-1; Sequence=Displayed; Name=2; IsoId=Q9NZ01-2; Sequence=VSP 005957;||TISSUE SPECIFICITY:Expressed in most tissues tested. Highly expressed in skeletal muscle.||SIMILARITY:Belongs to the steroid 5-alpha reductase family.

Subcellular localization

Endoplasmic reticulum membrane;Multi-pass membrane protein.

Gene name

trans-2,3-enoyl-CoA reductase

Protein sequence

MKHYEVEILDAKTREKLCFLDKVEPHATIAEIKNLFTKTH PQWYPARQSLRLDPKGKSLKDEDVLQKLPVGTTATLYFR DLGAQISWVTVFLTEYAGPLFIYLLFYFRVPFIYGHKYD FTSSRHTVVHLACICHSFHYIKRLLETLFVHRFSHGTMP LRNIFKNCTYYWGFAAWMAYYINHPLYTPPTYGAQQVKL ALAIFVICQLGNFSIHMALRDLRPAGSKTRKIPYPTKNP FTWLFLLVSCPNYTYEVGSWIGFAIMTQCLPVALFSLVG FTQMTIWAKGKHRSYLKEFRDYPPLRMPIIPFLL

Database cross reference

RefSeq Protein accession:NP_612510
RefSeq Protein gi:24475816

GO:0030176;C:integral to endoplasmic reticulum membrane;IDA:UniProtKB.

GO-F

GO:0019166;F:trans-2-enoyl-CoA reductase (NADPH) activity;IEA:EC. GO:0017099;F:very long-chain-acyl-CoA dehydrogenase activity;EXP:Reactome.

GO-P

GO:0030497;P:fatty acid elongation;IDA:UniProtKB. GO:0035338;P:long-chain fatty-acyl-CoA biosynthetic process;TAS:Reactome. GO:0055114;P:oxidation-reduction process;IEA:UniProtKB-KW. GO:0019432;P:triglyceride biosynthetic process;EXP:Reactome. GO:00427

MOD type1

Position1

Residue1

Source name1

source ID1

Source method

HLPP validation1 (Yes/no)

Quality score

HuLPr46846

PHOSPHORYLATION

28

T

PhosphoSitePlus

18010118

LTP

N

HuLPr46846

ACETYLATION

22

K

PhosphoSitePlus

11323915

HTP

N

IL2