HuLPr46848

Uniprot ID

TECT1_HUMAN

Uniprot Acc

Q2MV58;A8MX11;Q49A60;Q6P5X1;Q6UXW2;Q8NAE9;Q96N72;Q9H798;

Protein name

Tectonic-1

Comment

FUNCTION:Regulator of Hedgehog (Hh), required for both activation and inhibition of the Hh pathway in the patterning of the neural tube. During neural tube development, it is required for formation of the most ventral cell types and for full Hh pathway activation. Functions in Hh signal transduction to fully activate the pathway in the presence of high Hh levels and to repress the pathway in the absence of Hh signals. Modulates Hh signal transduction downstream of SMO and RAB23 (By similarity).||SUBCELLULAR LOCATION:Secreted (By similarity).||ALTERNATIVE PRODUCTS:Event=Alternative splicing; Named isoforms=6; Name=1; IsoId=Q2MV58-1; Sequence=Displayed; Name=2; IsoId=Q2MV58-2; Sequence=VSP 017763; Name=3; IsoId=Q2MV58-3; Sequence=VSP 017759; Name=4; IsoId=Q2MV58-4; Sequence=VSP 017757; Name=5; IsoId=Q2MV58-5; Sequence=VSP 017758, VSP 017761, VSP 017763; Name=6; IsoId=Q2MV58-6; Sequence=VSP 017756, VSP 017760, VSP 017762; Note=May be produced at very low levels due to a prem

Subcellular localization

Secreted(By similarity).

Gene name

tectonic family member 1

Protein sequence

MRPRGLPPLLVVLLGCWASVSAQTDATPAVTTEGLNSTEA ALATFGTFPSTRPPGTPRAPGPSSGPRPTPVTDVAVLCV CDLSPAQCDINCCCDPDCSSVDFSVFSACSVPVVTGDSQ FCSQKAVIYSLNFTANPPQRVFELVDQINPSIFCIHITN YKPALSFINPEVPDENNFDTLMKTSDGFTLNAESYVSFT TKLDIPTAAKYEYGVPLQTSDSFLRFPSSLTSSLCTDNN PAAFLVNQAVKCTRKINLEQCEEIEALSMAFYSSPEILR VPDSRKKVPITVQSIVIQSLNKTLTRREDTDVLQPTLVN AGHFSLCVNVVLEVKYSLTYTDAGEVTKADLSFVLGTVS SVVVPLQQKFEIHFLQENTQPVPLSGNPGYVVGLPLAAG FQPHKGSGIIQTTNRYGQLTILHSTTEQDCLALEGVRTP VLFGYTMQSGCKLRLTGALPCQLVAQKVKSLLWGQGFPD YVAPFGNSQAQDMLDWVPIHFITQSFNRKDSCQLPGALV IEVKWTKYGSLLNPQAKIVNVTANLISSSFPEANSGNER TILISTAVTFVDVSAPAEAGFRAPPAINARLPFNFFFPFV

Database cross reference

RefSeq Protein accession:NP_001076006
RefSeq Protein gi:130978357

HLPP validation

Yes/No

Yes

Project name

Chinese Liver;

GO:0005576;C:extracellular region;IEA:UniProtKB-SubCell.

GO-P

GO:0007275;P:multicellular organismal development;IEA:UniProtKB-KW.