Protein basic information
| LiverAtlas Protein ID |
HuLPr46880 |
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Uniprot ID |
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Uniprot Acc |
P55072;B2R5T8;Q0V924;Q2TAI5;Q969G7;Q9UCD5; |
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Protein name |
Transitional endoplasmic reticulum ATPase |
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Comment |
FUNCTION:Necessary for the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis. Involved in the formation of the transitional endoplasmic reticulum (tER). The transfer of membranes from the endoplasmic reticulum to the Golgi apparatus occurs via 50-70 nm transition vesicles which derive from part-rough, part-smooth transitional elements of the endoplasmic reticulum (tER). Vesicle budding from the tER is an ATP-dependent process. The ternary complex containing UFD1L, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1L-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope (By similarity). Regulates E3 ubiquitin-protein ligase activity of RNF19A.||SUBUNIT:Homohexamer. Forms a ring-shaped particle of 12.5 nm diameter, that displays 6-fold radial symmet |
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Subcellular localization |
Cytoplasm, cytosol.Nucleus. |
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Gene name |
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Related liver disease name |
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Protein sequence
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MASGADSKGDDLSTAILKQKNRPNRLIVDEAINEDNSVVS LSQPKMDELQLFRGDTVLLKGKKRREAVCIVLSDDTCSD EKIRMNRVVRNNLRVRLGDVISIQPCPDVKYGKRIHVLP IDDTVEGITGNLFEVYLKPYFLEAYRPIRKGDIFLVRGG MRAVEFKVVETDPSPYCIVAPDTVIHCEGEPIKREDEEE SLNEVGYDDIGGCRKQLAQIKEMVELPLRHPALFKAIGV KPPRGILLYGPPGTGKTLIARAVANETGAFFFLINGPEI MSKLAGESESNLRKAFEEAEKNAPAIIFIDELDAIAPKR EKTHGEVERRIVSQLLTLMDGLKQRAHVIVMAATNRPNS IDPALRRFGRFDREVDIGIPDATGRLEILQIHTKNMKLA DDVDLEQVANETHGHVGADLAALCSEAALQAIRKKMDLI DLEDETIDAEVMNSLAVTMDDFRWALSQSNPSALRETVV EVPQVTWEDIGGLEDVKRELQELVQYPVEHPDKFLKFGM TPSKGVLFYGPPGCGKTLLAKAIANECQANFISIKGPEL LTMWFGESEANVREIFDKARQAAPCVLFFDELDSIAKAR GGNIGDGGGAADRVINQILTEMDGMSTKKNVFIIGATNR PDIIDPAILRPGRLDQLIYIPLPDEKSRVAILKANLRKS PVAKDVDLEFLAKMTNGFSGADLTEICQRACKLAIRESI ESEIRRERERQTNPSAMEVEEDDPVPEIRRDHFEEAMRF ARRSVSDNDIRKYEMFAQTLQQSRGFGSFRFPSGNQGGA GPSQGSGGGTGGSVYTEDNDDDLYG |
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Database cross reference |
RefSeq Protein accession:NP_009057
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Liver relevance
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HCC significant Proteins |
Yes/No |
Yes |
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Quality score |
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HLPP validation |
Yes/No |
Yes |
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Project name |
Chinese Liver;French Liver;Human Fetal Liver;Human Liver Organelles; |
Ontology annotation
| GO-C |
GO:0005829;C:cytosol;IDA:UniProtKB. GO:0005783;C:endoplasmic reticulum;IDA:UniProtKB. GO:0005792;C:microsome;ISS:UniProtKB. GO:0005634;C:nucleus;IDA:UniProtKB. GO:0000502;C:proteasome complex;IDA:BHF-UCL. |
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GO-F |
GO:0005524;F:ATP binding;IEA:UniProtKB-KW. GO:0016887;F:ATPase activity;TAS:UniProtKB. GO:0008289;F:lipid binding;IEA:UniProtKB-KW. GO:0031593;F:polyubiquitin binding;IDA:BHF-UCL. GO:0019904;F:protein domain specific binding;IPI:UniProtKB. GO:0019903; |
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GO-P |
GO:0006919;P:activation of caspase activity;ISS:UniProtKB. GO:0006302;P:double-strand break repair;IDA:UniProtKB. GO:0030968;P:endoplasmic reticulum unfold |