HuLPr46891

Uniprot ID

TET3_HUMAN

Uniprot Acc

O43151;A6NEI3;Q86Z24;Q8TBM9;

Protein name

Methylcytosine dioxygenase TET3

Comment

FUNCTION:Catalyzes the conversion of methylcytosine (5mC) to 5- hydroxymethylcytosine (hmC) (By similarity).||CATALYTIC ACTIVITY:Methylcytosine + 2-oxoglutarate + O(2) = 5- hydroxymethylcytosine + succinate + CO(2).||COFACTOR:Binds 1 Fe(2+) ion per subunit (By similarity).||ALTERNATIVE PRODUCTS:Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=O43151-1; Sequence=Displayed; Name=2; IsoId=O43151-2; Sequence=VSP 021628; Note=No experimental confirmation available; Name=3; IsoId=O43151-3; Sequence=VSP 034192; Note=No experimental confirmation available;||TISSUE SPECIFICITY:Expressed in colon, muscle, adrenal gland and peripheral blood lymphocytes.||DEVELOPMENTAL STAGE:Expressed in fetal brain but not adult brain.||SIMILARITY:Belongs to the TET family.||SEQUENCE CAUTION:Sequence=AAH22243.1; Type=Erroneous initiation; Sequence=AAX93057.1; Type=Erroneous gene model prediction; Sequence=BAA23697.1; Type=Erroneous initiation;

Gene name

tet oncogene family member 3

Protein sequence

MDSGPVYHGDSRQLSASGVPVNGAREPAGPSLLGTGGPWR VDQKPDWEAAPGPAHTARLEDAHDLVAFSAVAEAVSSYG ALSTRLYETFNREMSREAGNNSRGPRPGPEGCSAGSEDL DTLQTALALARHGMKPPNCNCDGPECPDYLEWLEGKIKS VVMEGGEERPRLPGPLPPGEAGLPAPSTRPLLSSEVPQI SPQEGLPLSQSALSIAKEKNISLQTAIAIEALTQLSSAL PQPSHSTPQASCPLPEALSPPAPFRSPQSYLRAPSWPVV PPEEHSSFAPDSSAFPPATPRTEFPEAWGTDTPPATPRS SWPMPRPSPDPMAELEQLLGSASDYIQSVFKRPEALPTK PKVKVEAPSSSPAPAPSPVLQREAPTPSSEPDTHQKAQT ALQQHLHHKRSLFLEQVHDTSFPAPSEPSAPGWWPPPSS PVPRLPDRPPKEKKKKLPTPAGGPVGTEKAAPGIKPSVR KPIQIKKSRPREAQPLFPPVRQIVLEGLRSPASQEVQAH PPAPLPASQGSAVPLPPEPSLALFAPSPSRDSLLPPTQE MRSPSPMTALQPGSTGPLPPADDKLEELIRQFEAEFGDS FGLPGPPSVPIQDPENQQTCLPAPESPFATRSPKQIKIE SSGAVTVLSTTCFHSEEGGQEATPTKAENPLTPTLSGFL ESPLKYLDTPTKSLLDTPAKRAQAEFPTCDCVEQIVEKD EGPYYTHLGSGPTVASIRELMEERYGEKGKAIRIEKVIY TGKEGKSSRGCPIAKWVIRRHTLEEKLLCLVRHRAGHHC QNAVIVILILAWEGIPRSLGDTLYQELTDTLRKYGNPTS RRCGLNDDRTCACQGKDPNTCGASFSFGCSWSMYFNGCK YARSKTPRKFRLAGDNPKEEEVLRKSFQDLATEVAPLYK RLAPQAYQNQVTNEEIAIDCRLGLKEGRPFAGVTACMDF CAHAHKDQHNLYNGCTVVCTLTKEDNRCVGKIPEDEQLH VLPLYKMANTDEFGSEENQNAKVG

Database cross reference

RefSeq Protein accession:NP_659430
RefSeq Protein gi:149944516

HLPP validation

Yes/No

Yes

Project name

Human Liver Organelles;Chinese Liver;

GO-F

GO:0046872;F:metal ion binding;IEA:UniProtKB-KW. GO:0070579;F:methylcytosine dioxygenase activity;ISS:UniProtKB. GO:0016702;F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen;IE

GO-P

GO:0055114;P:oxidation-reduction process;IEA:UniProtKB-KW.