Choose one of the five choices you want to search:

Gene, Transcriptome, Protein, Pathway or Disease. 

Protein basic information

LiverAtlas Protein ID

HuLPr46928

Uniprot ID

TFB2M_HUMAN

Uniprot Acc

Q9H5Q4;Q9H626;

Protein name

Dimethyladenosine transferase 2, mitochondrial

Comment

FUNCTION:S-adenosyl-L-methionine-dependent methyltransferase which specifically dimethylates mitochondrial 12S rRNA at the conserved stem loop. Also required for basal transcription of mitochondrial DNA, probably via its interaction with POLRMT and TFAM. Stimulates transcription independently of the methyltransferase activity. Compared to TFB1M, it activates transcription of mitochondrial DNA more efficiently, while it has less methyltransferase activity.||SUBUNIT:Interacts with mitochondrial RNA polymerase POLRMT. Interacts with TFAM.||INTERACTION:Q00059:TFAM; NbExp=1; IntAct=EBI-1043912, EBI-1049924;||SUBCELLULAR LOCATION:Mitochondrion.||TISSUE SPECIFICITY:Ubiquitously expressed.||INDUCTION:By the nuclear respiratory factors NRF1 and NRF2/GABPB2 and PGC-1 coactivators.||SIMILARITY:Belongs to the methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. KsgA subfamily.||SEQUENCE CAUTION:Sequence=BAB15441.1; Type=Erroneous initiation;

Subcellular localization

Mitochondrion.

Gene name

transcription factor B2, mitochondrial

Protein sequence

MWIPVVGLPRRLRLSALAGAGRFCILGSEAATRKHLPARN HCGLSDSSPQLWPEPDFRNPPRKASKASLDFKRYVTDRR LAETLAQIYLGKPSRPPHLLLECNPGPGILTQALLEAGA KVVALESDKTFIPHLESLGKNLDGKLRVIHCDFFKLDPR SGGVIKPPAMSSRGLFKNLGIEAVPWTADIPLKVVGMFP SRGEKRALWKLAYDLYSCTSIYKFGRIEVNMFIGEKEFQ KLMADPGNPDLYHVLSVIWQLACEIKVLHMEPWSSFDIY TRKGPLENPKRRELLDQLQQKLYLIQMIPRQNLFTKNLT PMNYNIFFHLLKHCFGRRSATVIDHLRSLTPLDARDILM QIGKQEDEKVVNMHPQDFKTLFETIERSKDCAYKWLYDETLEDR

Database cross reference

RefSeq Protein accession:NP_071761
RefSeq Protein gi:11641289

Liver relevance

HLPP validation

Yes/No

Yes

Project name

Human Liver Organelles;

Ontology annotation

GO-C

GO:0042645;C:mitochondrial nucleoid;IDA:BHF-UCL.

GO-F

GO:0005515;F:protein binding;IPI:IntAct. GO:0000179;F:rRNA (adenine-N6,N6-)-dimethyltransferase activity;IEA:InterPro. GO:0003712;F:transcription cofactor activity;IDA:UniProtKB.

GO-P

GO:0045893;P:positive regulation of transcription, DNA-dependent;IDA:UniProtKB. GO:0006391;P:transcription initiation from mitochondrial promoter;IDA:UniProtKB.