Protein basic information
| LiverAtlas Protein ID |
HuLPr46946 |
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Uniprot ID |
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Uniprot Acc |
P02786;D3DXB0;Q1HE24;Q59G55;Q9UCN0;Q9UCU5;Q9UDF9;Q9UK21; |
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Protein name |
Transferrin receptor protein 1 |
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Comment |
FUNCTION:Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity). A second ligand, the heditary hemochromatosis protein HFE, competes for binding with transferrin for an overlapping C-terminal binding site.||SUBUNIT:Homodimer; disulfide-linked. Binds one transferrin or HFE molecule per subunit. Binds the HLA class II histocompatibility antigen, DR1. Interacts with SH3BP3. Interacts with Machupo arenavirus GPC.||SUBCELLULAR LOCATION:Cell membrane; Single-pass type II membrane protein. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV.||SUBCELLU |
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Subcellular localization |
Cell membrane;Single-pass type II membrane protein.Melanosome. |
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Gene name |
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Related liver disease name |
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Protein sequence
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MMDQARSAFSNLFGGEPLSYTRFSLARQVDGDNSHVEMKL AVDEEENADNNTKANVTKPKRCSGSICYGTIAVIVFFLI GFMIGYLGYCKGVEPKTECERLAGTESPVREEPGEDFPA ARRLYWDDLKRKLSEKLDSTDFTGTIKLLNENSYVPREA GSQKDENLALYVENQFREFKLSKVWRDQHFVKIQVKDSA QNSVIIVDKNGRLVYLVENPGGYVAYSKAATVTGKLVHA NFGTKKDFEDLYTPVNGSIVIVRAGKITFAEKVANAESL NAIGVLIYMDQTKFPIVNAELSFFGHAHLGTGDPYTPGF PSFNHTQFPPSRSSGLPNIPVQTISRAAAEKLFGNMEGD CPSDWKTDSTCRMVTSESKNVKLTVSNVLKEIKILNIFG VIKGFVEPDHYVVVGAQRDAWGPGAAKSGVGTALLLKLA QMFSDMVLKDGFQPSRSIIFASWSAGDFGSVGATEWLEG YLSSLHLKAFTYINLDKAVLGTSNFKVSASPLLYTLIEK TMQNVKHPVTGQFLYQDSNWASKVEKLTLDNAAFPFLAY SGIPAVSFCFCEDTDYPYLGTTMDTYKELIERIPELNKV ARAAAEVAGQFVIKLTHDVELNLDYERYNSQLLSFVRDL NQYRADIKEMGLSLQWLYSARGDFFRATSRLTTDFGNAE KTDRFVMKKLNDRVMRVEYHFLSPYVSPKESPFRHVFWG SGSHTLPALLENLKLRKQNNGAFNETLFRNQLALATWTI QGAANALSGDVWDIDNEF |
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Database cross reference |
RefSeq Protein accession:NP_001121620
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Liver relevance
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HCC significant Proteins |
Yes/No |
Yes |
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Quality score |
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HLPP validation |
Yes/No |
Yes |
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Project name |
Chinese Liver;Human Liver Organelles; |
Ontology annotation
| GO-C |
GO:0005905;C:coated pit;IDA:UniProtKB. GO:0005768;C:endosome;IDA:MGI. GO:0005887;C:integral to plasma membrane;TAS:ProtInc. GO:0042470;C:melanosome;IEA:UniProtKB-SubCell. |
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GO-F |
GO:0008233;F:peptidase activity;IEA:InterPro. GO:0004998;F:transferrin receptor activity;NAS:UniProtKB. |
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GO-P |
GO:0006879;P:cellular iron ion homeostasis;NAS:UniProtKB. GO:0006897;P:endocytosis;IEA:UniProtKB-KW. GO:0044419;P:interspecies interaction between organisms;IEA:UniProtKB-KW. GO:0006508;P:proteolysis;IEA:InterPro |