Protein basic information
| LiverAtlas Protein ID |
HuLPr46947 |
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Uniprot ID |
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Uniprot Acc |
Q9UP52;A6NGM7;O75422;Q1HE13;Q9HA99;Q9NX67; |
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Protein name |
Transferrin receptor protein 2 |
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Comment |
FUNCTION:Mediates cellular uptake of transferrin-bound iron in a non-iron dependent manner. May be involved in iron metabolism, hepatocyte function and erythrocyte differentiation.||SUBUNIT:Homodimer.||SUBCELLULAR LOCATION:Cell membrane; Single-pass type II membrane protein.||SUBCELLULAR LOCATION:Isoform Beta:Cytoplasm (Probable). Note=Lacks the transmembrane domain. Probably intracellular.||ALTERNATIVE PRODUCTS:Event=Alternative splicing; Named isoforms=3; Name=Alpha; IsoId=Q9UP52-1; Sequence=Displayed; Name=Beta; IsoId=Q9UP52-2; Sequence=VSP 005354; Name=Gamma; IsoId=Q9UP52-3; Sequence=VSP 005355;||TISSUE SPECIFICITY:Predominantly expressed in liver. While the alpha form is also expressed in spleen, lung, muscle, prostate and peripheral blood mononuclear cells, the beta form is expressed in all tissues tested, albeit weakly.||DISEASE:Defects in TFR2 are a cause of hemochromatosis type 3 (HFE3) [MIM:604250]. HFE3 is a disorder of iron hemostasis resulting in iron overload and ha |
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Subcellular localization |
Cell membrane;Single-pass type II membrane protein. |
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Gene name |
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Related liver disease name |
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Protein sequence
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MERLWGLFQRAQQLSPRSSQTVYQRVEGPRKGHLEEEEED GEEGAETLAHFCPMELRGPEPLGSRPRQPNLIPWAAAGR RAAPYLVLTALLIFTGAFLLGYVAFRGSCQACGDSVLVV SEDVNYEPDLDFHQGRLYWSDLQAMFLQFLGEGRLEDTI RQTSLRERVAGSAGMAALTQDIRAALSRQKLDHVWTDTH YVGLQFPDPAHPNTLHWVDEAGKVGEQLPLEDPDVYCPY SAIGNVTGELVYAHYGRPEDLQDLRARGVDPVGRLLLVR VGVISFAQKVTNAQDFGAQGVLIYPEPADFSQDPPKPSL SSQQAVYGHVHLGTGDPYTPGFPSFNQTQFPPVASSGLP SIPAQPISADIASRLLRKLKGPVAPQEWQGSLLGSPYHL GPGPRLRLVVNNHRTSTPINNIFGCIEGRSEPDHYVVIG AQRDAWGPGAAKSAVGTAILLELVRTFSSMVSNGFRPRR SLLFISWDGGDFGSVGSTEWLEGYLSVLHLKAVVYVSLD NAVLGDDKFHAKTSPLLTSLIESVLKQVDSPNHSGQTLY EQVVFTNPSWDAEVIRPLPMDSSAYSFTAFVGVPAVEFS FMEDDQAYPFLHTKEDTYENLHKVLQGRLPAVAQAVAQL AGQLLIRLSHDRLLPLDFGRYGDVVLRHIGNLNEFSGDL KARGLTLQWVYSARGDYIRAAEKLRQEIYSSEERDERLT RMYNVRIMRVEFYFLSQYVSPADSPFRHIFMGRGDHTLG ALLDHLRLLRSNSSGTPGATSSTGFQESRFRRQLALLTW TLQGAANALSGDVWNIDNNF |
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Database cross reference |
RefSeq Protein accession:NP_003218
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Liver relevance
| Liver sepcificity |
Yes/No |
Yes |
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Evidence |
Translational level from literatures |
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Quality score |
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HCC significant Proteins |
Yes/No |
Yes |
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Quality score |
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Ontology annotation
| GO-C |
GO:0005737;C:cytoplasm;IEA:UniProtKB-SubCell. GO:0005887;C:integral to plasma membrane;NAS:UniProtKB. |
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GO-F |
GO:0008233;F:peptidase activity;IEA:InterPro. GO:0004998;F:transferrin receptor activity;NAS:UniProtKB. |
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