Protein basic information
| LiverAtlas Protein ID |
HuLPr46951 |
|
Uniprot ID |
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Uniprot Acc |
Q8WUH2;A8K5R7;D3DVJ8;O60466; |
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Protein name |
Transforming growth factor-beta receptor-associated protein 1 |
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Comment |
FUNCTION:Plays a role in the TGF-beta/activin signaling pathway. It associates with inactive heteromeric TGF-beta and activin receptor complexes, mainly through the type II receptor, and is released upon activation of signaling. May recruit SMAD4 to the vicinity of the receptor complex and facilitate its interaction with receptor-regulated Smads, such as SMAD2.||SUBUNIT:Interacts with TGFBR2 and ACVR2B; in the absence of ligand stimulation. Interacts with TGFBR1, ACVRL1, BMPR1A and ACVR1B; in the absence of ligand stimulation and to a less extent. Interacts with SMAD4; the interaction seems to be mutually exclusive with the interaction of SMAD4 and phosphorylated SMAD2. May interact with ALOX5.||SUBCELLULAR LOCATION:Cytoplasm. Note=Colocalizes with TGF-beta receptors in the absence of signaling.||SIMILARITY:Belongs to the TRAP1 family.||SIMILARITY:Contains 1 CNH domain.||CAUTION:In (PubMed:9545258) and in (PubMed:10051563) experimental information is given for a truncated version of TG |
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Subcellular localization |
Cytoplasm. |
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Gene name |
transforming growth factor, beta receptor associated protein 1 |
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Protein sequence
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MMSIKAFTLVSAVERELLMGDKERVNIECVECCGRDLYVG TNDCFVYHFLLEERPVPAGPATFTATKQLQRHLGFKKPV NELRAASALNRLLVLCDNSISLVNMLNLEPVPSGARIKG AATFALNENPVSGDPFCVEVCIISVKRRTIQMFLVYEDR VQIVKEVSTAEQPLAVAVDGHFLCLALTTQYIIHNYSTG VSQDLFPYCSEERPPIVKRIGRQEFLLAGPGGLGMFATV AGISQRAPVHWSENVIGAAVSFPYVIALDDEFITVHSML DQQQKQTLPFKEGHILQDFEGRVIVATSKGVYILVPLPL EKQIQDLLASRRVEEALVLAKGARRNIPKEKFQVMYRRI LQQAGFIQFAQLQFLEAKELFRSGQLDVRELISLYPFLL PTSSSFTRSHPPLHEYADLNQLTQGDQEKMAKCKRFLMS YLNEVRSTEVANGYKEDIDTALLKLYAEADHDSLLDLLV TENFCLLTDSAAWLEKHKKYFALGLLYHYNNQDAAAVQL WVNIVNGDVQDSTRSDLYEYIVDFLTYCLDEELVWAYAD WVLQKSEEVGVQVFTKRPLDEQQKNSFNPDDIINCLKKY PKALVKYLEHLVIDKRLQKEEYHTHLAVLYLEEVLLQRA SASGKGAEATETQAKLRRLLQKSDLYRVHFLLERLQGAG LPMESAILHGKLGEHEKALHILVHELQDFAAAEDYCLWC SEGRDPPHRQQLFHTLLAIYLHAGPTAHELAVAAVDLLN RHATEFDAAQVLQMLPDTWSVQLLCPFLMGAMRDSIHAR RTMQVALGLARSENLIYTYDKMKLKGSSIQLSDKKLCQI CQNPFCEPVFVRYPNGGLVHTHCAASRHTNPSSSSPGTRT |
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Database cross reference |
RefSeq Protein accession:NP_001136093
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Ontology annotation
| GO-C |
GO:0005737;C:cytoplasm;IEA:UniProtKB-SubCell. GO:0016020;C:membrane;IDA:UniProtKB. |
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GO-F |
GO:0046332;F:SMAD binding;IDA:UniProtKB. GO:0005083;F:small GTPase regulator activity;IEA:InterPro. GO:0005160;F:transforming growth factor beta receptor binding;IDA:UniProtKB. |
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GO-P |
GO:0006355;P:regulation of transcription, DNA-dependent;IDA:UniProtKB. GO:0007179;P:transforming growth factor beta receptor signaling pathway;TAS:UniProtKB. |
Post-translational modification
| LiverAtlas Protein ID |
MOD type1 |
Position1 |
Residue1 |
Source name1 |
source ID1 |
Source method |
HLPP validation1 (Yes/no) |
Quality score |
|
HuLPr46951 |
PHOSPHORYLATION |
855 |
S |
PhosphoSitePlus |
LTP |
N |
 
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Pathway
| Pathway name | |
| Pathway name |
