HuLPr47008

Uniprot ID

THRB_HUMAN

Uniprot Acc

P00734;B2R7F7;B4E1A7;Q4QZ40;Q53H04;Q53H06;Q7Z7P3;Q9UCA1;

Protein name

Prothrombin

Comment

FUNCTION:Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing.||CATALYTIC ACTIVITY:Selective cleavage of Arg-|-Gly bonds in fibrinogen to form fibrin and release fibrinopeptides A and B.||INTERACTION:Q846V4:- (xeno); NbExp=3; IntAct=EBI-297094, EBI-989571; P07204:THBD; NbExp=1; IntAct=EBI-297094, EBI-941422;||SUBCELLULAR LOCATION:Secreted, extracellular space.||TISSUE SPECIFICITY:Expressed by the liver and secreted in plasma.||PTM:The gamma-carboxyglutamyl residues, which bind calcium ions, result from the carboxylation of glutamyl residues by a microsomal enzyme, the vitamin K-dependent carboxylase. The modified residues are necessary for the calcium-dependent interaction with a negatively charged phospholipid surface, which is essential for the conversion of prothrombin to thrombin.||DISEASE:Defects in F2 ar

Subcellular localization

Secreted, extracellular space.

Gene name

coagulation factor II (thrombin)

Related liver disease name

Hepatocellular carcinoma

Protein sequence

MAHVRGLQLPGCLALAALCSLVHSQHVFLAPQQARSLLQR VRRANTFLEEVRKGNLERECVEETCSYEEAFEALESSTA TDVFWAKYTACETARTPRDKLAACLEGNCAEGLGTNYRG HVNITRSGIECQLWRSRYPHKPEINSTTHPGADLQENFC RNPDSSTTGPWCYTTDPTVRRQECSIPVCGQDQVTVAMT PRSEGSSVNLSPPLEQCVPDRGQQYQGRLAVTTHGLPCL AWASAQAKALSKHQDFNSAVQLVENFCRNPDGDEEGVWC YVAGKPGDFGYCDLNYCEEAVEEETGDGLDEDSDRAIEG RTATSEYQTFFNPRTFGSGEADCGLRPLFEKKSLEDKTE RELLESYIDGRIVEGSDAEIGMSPWQVMLFRKSPQELLC GASLISDRWVLTAAHCLLYPPWDKNFTENDLLVRIGKHS RTRYERNIEKISMLEKIYIHPRYNWRENLDRDIALMKLK KPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLK ETWTANVGKGQPSVLQVVNLPIVERPVCKDSTRIRITDN MFCAGYKPDEGKRGDACEGDSGGPFVMKSPFNNRWYQMG IVSWGEGCDRDGKYGFYTHVFRLKKWIQKVIDQFGE

Database cross reference

RefSeq Protein accession:NP_000497
RefSeq Protein gi:4503635

HCC significant Proteins

Yes/No

Yes

Quality score

HLPP validation

Yes/No

Yes

Project name

Chinese Liver;Human Fetal Liver;Human Liver Organelles;

GO:0005788;C:endoplasmic reticulum lumen;TAS:Reactome. GO:0005615;C:extracellular space;IDA:BHF-UCL. GO:0005796;C:Golgi lumen;TAS:Reactome. GO:0005886;C:plasma membrane;EXP:Reactome. GO:0005625;C:soluble fraction;TAS:ProtInc.

GO-F

GO:0005509;F:calcium ion binding;IEA:InterPro. GO:0008083;F:growth factor activity;TAS:BHF-UCL. GO:0004252;F:serine-type endopeptidase activity;IDA:UniProtKB. GO:0070053;F:thrombospondin receptor activity;IDA:BHF-UCL.

GO-P

GO:0006919;P:activation of caspase activity;TAS:ProtInc. GO:0006953;P:acute-phase response;IEA:UniProtKB-KW. GO:0007597;P:blood coagulation, intrinsic pathway;TAS:Reactome. GO:0007166;P:cell surface receptor linked signaling pathway;IDA:BHF-UCL. GO:005