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Gene, Transcriptome, Protein, Pathway or Disease. 

Protein basic information

LiverAtlas Protein ID

HuLPr47043

Uniprot ID

TIGAR_HUMAN

Uniprot Acc

Q9NQ88;B2R840;

Protein name

Probable fructose-2,6-bisphosphatase TIGAR

Comment

FUNCTION:Probable fructose-biphosphatase. Lowers cellular levels of fructose 2,6-bisphosphate. Protects cells against reactive oxygen species and against apoptosis induced by p53/TP53.||CATALYTIC ACTIVITY:Beta-D-fructose 2,6-bisphosphate + H(2)O = D- fructose 6-phosphate + phosphate.||INDUCTION:Rapidly up-regulated by p53/TP53.||PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.||SIMILARITY:Belongs to the phosphoglycerate mutase family.||CAUTION:Not expected to have any kinase activity.

Gene name

chromosome 12 open reading frame 5

Protein sequence

MARFALTVVRHGETRFNKEKIIQGQGVDEPLSETGFKQAA AAGIFLNNVKFTHAFSSDLMRTKQTMHGILERSKFCKDM TVKYDSRLRERKYGVVEGKALSELRAMAKAAREECPVFT PPGGETLDQVKMRGIDFFEFLCQLILKEADQKEQFSQGS PSNCLETSLAEIFPLGKNHSSKVNSDSGIPGLAASVLVV SHGAYMRSLFDYFLTDLKCSLPATLSRSELMSVTPNTGM SLFIINFEEGREVKPTVQCICMNLQDHLNGLTETR

Database cross reference

RefSeq Protein accession:NP_065108
RefSeq Protein gi:9966849

Liver relevance

HLPP validation

Yes/No

Yes

Project name

Chinese Liver;Human Liver Organelles;

Ontology annotation

GO-C

GO:0005622;C:intracellular;IDA:LIFEdb.

GO-F

GO:0004331;F:fructose-2,6-bisphosphate 2-phosphatase activity;IEA:EC.

Post-translational modification

LiverAtlas Protein ID

MOD type1

Position1

Residue1

Source name1

source ID1

Source method

HLPP validation1 (Yes/no)

Quality score

HuLPr47043

ACETYLATION

50

K

PhosphoSitePlus

11322572

HTP

N

HuLPr47043

PHOSPHORYLATION

154

S

PhosphoSitePlus

472300

LTP

HTP

N

HuLPr47043

PHOSPHORYLATION

34

T

PhosphoSitePlus

2526844

LTP

N

Pathway

Pathway name

Direct_p53_effectors