Protein basic information
| LiverAtlas Protein ID |
HuLPr47096 |
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Uniprot ID |
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Uniprot Acc |
Q9Y490;A6NMY0;Q86YD0;Q9NZQ2;Q9UHH8;Q9UPX3; |
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Protein name |
Talin-1 |
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Comment |
FUNCTION:Probably involved in connections of major cytoskeletal structures to the plasma membrane. High molecular weight cytoskeletal protein concentrated at regions of cell-substratum contact and, in lymphocytes, at cell-cell contacts (By similarity).||SUBUNIT:Binds with high affinity to vinculin and with low affinity to integrins. Interacts with PIP5K1C and NRAP. Interacts with LAYN. Interacts with SYNM.||SUBCELLULAR LOCATION:Cell projection, ruffle membrane; Peripheral membrane protein; Cytoplasmic side (By similarity). Cytoplasm, cytoskeleton (By similarity). Note=Colocalizes with LAYN at the membrane ruffles (By similarity).||SIMILARITY:Contains 1 FERM domain.||SIMILARITY:Contains 1 I/LWEQ domain.||SEQUENCE CAUTION:Sequence=BAA82979.2; Type=Erroneous initiation; |
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Subcellular localization |
Cell projection, ruffle membrane;Peripheral membrane protein;Cytoplasmic side(By similarity).Cytoplasm, cytoskeleton(By similarity). |
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Gene name |
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Related liver disease name |
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Protein sequence
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MVALSLKISIGNVVKTMQFEPSTMVYDACRIIRERIPEAP AGPPSDFGLFLSDDDPKKGIWLEAGKALDYYMLRNGDTM EYRKKQRPLKIRMLDGTVKTIMVDDSKTVTDMLMTICAR IGITNHDEYSLVRELMEEKKEEITGTLRKDKTLLRDEKK MEKLKQKLHTDDELNWLDHGRTLREQGVEEHETLLLRRK FFYSDQNVDSRDPVQLNLLYVQARDDILNGSHPVSFDKA CEFAGFQCQIQFGPHNEQKHKAGFLDLKDFLPKEYVKQK GERKIFQAHKNCGQMSEIEAKVRYVKLARSLKTYGVSFF LVKEKMKGKNKLVPRLLGITKECVMRVDEKTKEVIQEWN LTNIKRWAASPKSFTLDFGDYQDGYYSVQTTEGEQIAQL IAGYIDIILKKKKSKDHFGLEGDEESTMLEDSVSPKKST VLQQQYNRVGKVEHGSVALPAIMRSGASGPENFQVGSMP PAQQQITSGQMHRGHMPPLTSAQQALTGTINSSMQAVQA AQATLDDFDTLPPLGQDAASKAWRKNKMDESKHEIHSQV DAITAGTASVVNLTAGDPAETDYTAVGCAVTTISSNLTE MSRGVKLLAALLEDEGGSGRPLLQAAKGLAGAVSELLRS AQPASAEPRQNLLQAAGNVGQASGELLQQIGESDTDPHF QDALMQLAKAVASAAAALVLKAKSVAQRTEDSGLQTQVI AAATQCALSTSQLVACTKVVAPTISSPVCQEQLVEAGRL VAKAVEGCVSASQAATEDGQLLRGVGAAATAVTQALNEL LQHVKAHATGAGPAGRYDQATDTILTVTENIFSSMGDAG EMVRQARILAQATSDLVNAIKADAEGESDLENSRKLLSA AKILADATAKMVEAAKGAAAHPDSEEQQQRLREAAEGLR MATNAAAQNAIKKKLVQRLEHAAKQAAASATQTIAAAQH AASTPKASAGPQPLLVQSCKAVAEQIPLLVQGVRGSQAQ PDSPSAQLALIAASQSFLQPGGKM |
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Database cross reference |
RefSeq Protein accession:NP_006280
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Liver relevance
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HCC significant Proteins |
Yes/No |
Yes |
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Quality score |
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HLPP validation |
Yes/No |
Yes |
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Project name |
Chinese Liver;French Liver;Human Fetal Liver;Human Liver Organelles; |
Ontology annotation
| GO-C |
GO:0015629;C:actin cytoskeleton;IEA:InterPro. GO:0005911;C:cell-cell junction;IC:UniProtKB. GO:0005813;C:centrosome;IDA:HPA. GO:0005829;C:cytosol;EXP:Reactome. GO:0005576;C:extracellular region;EXP:Reactome. GO:0005925;C:focal adhesion;NAS:UniProtKB.| |
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GO-F |
GO:0003779;F:actin binding;IEA:InterPro. GO:0005158;F:insulin receptor binding;IEA:InterPro. GO:0030274;F:LIM domain binding;IPI:UniProtKB. GO:0005200;F:structural constituent of cytoskeleton;NAS:UniProtKB. GO:0017166;F:vinculin binding;IPI:UniProtKB. |
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GO-P |
GO:0007411;P:axon guidance;TAS:Reactome. GO:0007155;P:cell adhesion;IEA:InterP |