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Protein basic information

LiverAtlas Protein ID

HuLPr47197

Uniprot ID

TM2D1_HUMAN

Uniprot Acc

Q9BX74;A6NDA8;

Protein name

TM2 domain-containing protein 1

Comment

FUNCTION:May participate to beta-amyloid-induced apoptosis via its interaction with beta-APP42.||SUBUNIT:Interacts with beta-APP42 (beta-amyloid protein 42) peptide of APP.||SUBCELLULAR LOCATION:Membrane; Multi-pass membrane protein.||TISSUE SPECIFICITY:Widely expressed.||PTM:N-glycosylated.||SIMILARITY:Belongs to the TM2 family.||CAUTION:Was originally (PubMed:11278849) thought to modulate beta-amyloid toxicity by coupling to G protein. However, PubMed:12836168 showed that this effect is not direct.

Subcellular localization

Membrane;Multi-pass membrane protein.

Gene name

TM2 domain containing 1

Protein sequence

MAAAWPSGPSAPEAVTARLVGVLWFVSVTTGPWGAVATSA GGEESLKCEDLKVGQYICKDPKINDATQEPVNCTNYTAH VSCFPAPNITCKDSSGNETHFTGNEVGFFKPISCRNVNG YSYKVAVALSLFLGWLGADRFYLGYPALGLLKFCTVGFC GIGSLIDFILISMQIVGPSDGSSYIIDYYGTRLTRLSIT NETFRKTQLYP

Database cross reference

RefSeq Protein accession:NP_114416
RefSeq Protein gi:14042945

Liver relevance

HLPP validation

Yes/No

Yes

Project name

Chinese Liver;Human Liver Organelles;

Ontology annotation

GO-P

GO:0006915;P:apoptosis;IEA:UniProtKB-KW.