Choose one of the five choices you want to search:

Gene, Transcriptome, Protein, Pathway or Disease. 

Protein basic information

LiverAtlas Protein ID

HuLPr47240

Uniprot ID

TMC6_HUMAN

Uniprot Acc

Q7Z403;O43284;Q45VJ2;Q8IU98;Q8IUI7;Q8IWU8;Q8TEQ7;Q9HAG5;

Protein name

Transmembrane channel-like protein 6

Comment

SUBCELLULAR LOCATION:Endoplasmic reticulum membrane; Multi-pass membrane protein.||ALTERNATIVE PRODUCTS:Event=Alternative splicing; Named isoforms=4; Name=1; Synonyms=Large EVER1; IsoId=Q7Z403-1; Sequence=Displayed; Name=2; Synonyms=Small EVER1; IsoId=Q7Z403-2; Sequence=VSP 016439; Name=3; IsoId=Q7Z403-3; Sequence=VSP 016437, VSP 016440; Note=No experimental confirmation available; Name=4; IsoId=Q7Z403-4; Sequence=VSP 016438, VSP 016441, VSP 016442; Note=No experimental confirmation available;||TISSUE SPECIFICITY:Expressed in placenta, prostate, testis, activated T-lymphocytes and lymphokine-activated killer (LAK) lymphocytes.||DISEASE:Defects in TMC6 are a cause of epidermodysplasia verruciformis (EV) [MIM:226400]. It is a rare autosomal recessive genodermatosis associated with a high risk of skin carcinoma that results from an abnormal susceptibility to infection by specific human papillomaviruses. Infection leads to persistent wart-like or macular lesions.||SIMILARITY:Be

Subcellular localization

Endoplasmic reticulum membrane;Multi-pass membrane protein.

Gene name

transmembrane channel-like 6

Protein sequence

MAQPLAFILDVPETPGDQGQGPSPYDESEVHDSFQQLIQE QSQCTAQEGLELQQREREVTGSSQQTLWRPEGTQSTATL RILASMPSRTIGRSRGAIISQYYNRTVQLRCRSSRPLLG NFVRSAWPSLRLYDLELDPTALEEEEKQSLLVKELQSLA VAQRDHMLRGMPLSLAEKRSLREKSRTPRGKWRGQPGSG GVCSCCGRLRYACVLALHSLGLALLSALQALMPWRYALK RIGGQFGSSVLSYFLFLKTLLAFNALLLLLLVAFIMGPQ VAFPPALPGPAPVCTGLELLTGAGCFTHTVMYYGHYSNA TLNQPCGSPLDGSQCTPRVGGLPYNMPLAYLSTVGVSFF ITCITLVYSMAHSFGESYRVGSTSGIHAITVFCSWDYKV TQKRASRLQQDNIRTRLKELLAEWQLRHSPRSVCGRLRQ AAVLGLVWLLCLGTALGCAVAVHVFSEFMIQSPEAAGQE AVLLVLPLVVGLLNLGAPYLCRVLAALEPHDSPVLEVYV AICRNLILKLAILGTLCYHWLGRRVGVLQGQCWEDFVGQ ELYRFLVMDFVLMLLDTLFGELVWRIISEKKLKRRRKPE FDIARNVLELIYGQTLTWLGVLFSPLLPAVQIIKLLLVF YVKKTSLLANCQAPRRPWLASHMSTVFLTLLCFPAFLGA AVFLCYAVWQVKPSSTCGPFRTLDTMYEAGRVWVRHLEA AGPRVSWLPWVHRYLMENTFFVFLVSALLLAVIYLNIQV VRGQRKVICLLKEQISNEGEDKIFLINKLHSIYERKERE ERSRVGTTEEAAAPPALLTDEQDA

Database cross reference

RefSeq Protein accession:NP_001120670
RefSeq Protein gi:187608791

Liver relevance

HLPP validation

Yes/No

Yes

Project name

French Liver;

Ontology annotation

GO-C

GO:0005789;C:endoplasmic reticulum membrane;IEA:UniProtKB-SubCell. GO:0016021;C:integral to membrane;IEA:UniProtKB-KW.