Protein basic information
| LiverAtlas Protein ID |
HuLPr47293 |
|
Uniprot ID |
|
|
Uniprot Acc |
Q9BXS4;B3KQL7;O75393;Q4VBP9;Q5T705;Q96KX7; |
|
Protein name |
Transmembrane protein 59 |
|
Comment |
FUNCTION:Modulates the O-glycosylation and complex N- glycosylation steps occurring during the Golgi maturation of several proteins such as APP, BACE1, SEAP or PRNP. Inhibits APP transport to the cell surface and further shedding.||SUBCELLULAR LOCATION:Golgi apparatus membrane; Single-pass type I membrane protein.||PTM:N-glycosylated.||SIMILARITY:Belongs to the TMEM59 family.||SEQUENCE CAUTION:Sequence=AAC39890.1; Type=Frameshift; Positions=6; Sequence=AAH03106.1; Type=Erroneous initiation; |
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Subcellular localization |
Golgi apparatus membrane;Single-pass type I membrane protein. |
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Gene name |
|
|
Protein sequence
|
MAAPKGSLWVRTQLGLPPLLLLTMALAGGSGTASAEAFDS VLGDTASCHRACQLTYPLHTYPKEEELYACQRGCRLFSI CQFVDDGIDLNRTKLECESACTEAYSQSDEQYACHLGCQ NQLPFAELRQEQLMSLMPKMHLLFPLTLVRSFWSDMMDS AQSFITSSWTFYLQADDGKIVIFQSKPEIQYAPHLEQEP TNLRESSLSKMSYLQMRNSQAHRNFLEDGESDGFLRCLS LNSGWILTTTLVLSVMVLLWICCATVATAVEQYVPSEKL SIYGDLEFMNEQKLNRYPASSLVVVRSKTEDHEEAGPLP TKVNLAHSEI |
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Database cross reference |
RefSeq Protein accession:NP_004863
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Liver relevance
|
HLPP validation |
Yes/No |
Yes |
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Project name |
Chinese Liver; |
Ontology annotation
| GO-C |
GO:0000139;C:Golgi membrane;IEA:UniProtKB-SubCell. GO:0016021;C:integral to membrane;IEA:UniProtKB-KW. |
Post-translational modification
| LiverAtlas Protein ID |
MOD type1 |
Position1 |
Residue1 |
Source name1 |
source ID1 |
Source method |
HLPP validation1 (Yes/no) |
Quality score |
|
HuLPr47293 |
PHOSPHORYLATION |
133 |
S |
PhosphoSitePlus |
LTP |
N |
 
|
|
|
HuLPr47293 |
PHOSPHORYLATION |
321 |
S |
PhosphoSitePlus |
LTP |
N |
|
