HuLPr47343

Uniprot ID

TMX2_HUMAN

Uniprot Acc

Q9Y320;B7Z4R4;Q53G73;Q561W0;Q5J7Q7;Q8NBP9;Q9H3L1;

Protein name

Thioredoxin-related transmembrane protein 2

Comment

SUBCELLULAR LOCATION:Membrane; Single-pass type I membrane protein (Potential).||ALTERNATIVE PRODUCTS:Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9Y320-1; Sequence=Displayed; Name=2; IsoId=Q9Y320-2; Sequence=VSP 030696;||TISSUE SPECIFICITY:Widely expressed.||DOMAIN:The thioredoxin domain lacks the 2 redox-active cysteines, suggesting that it lacks thioredoxin activity (By similarity).||DOMAIN:The di-lysine motif confers endoplasmic reticulum localization for type I membrane proteins (By similarity).||SIMILARITY:Contains 1 thioredoxin domain.||SEQUENCE CAUTION:Sequence=AAG43122.1; Type=Frameshift; Positions=283; Sequence=BAC11569.1; Type=Frameshift; Positions=282;

Subcellular localization

Membrane;Single-pass type I membrane protein(Potential).

Gene name

thioredoxin-related transmembrane protein 2

Protein sequence

MAVLAPLIALVYSVPRLSRWLAQPYYLLSALLSAAFLLVR KLPPLCHGLPTQREDGNPCDFDWREVEILMFLSAIVMMK NRRSITVEQHIGNIFMFSKVANTILFFRLDIRMGLLYIT LCIVFLMTCKPPLYMGPEYIKYFNDKTIDEELERDKRVT WIVEFFANWSNDCQSFAPIYADLSLKYNCTGLNFGKVDV GRYTDVSTRYKVSTSPLTKQLPTLILFQGGKEAMRRPQI DKKGRAVSWTFSEENVIREFNLNELYQRAKKLSKAGDNI PEEQPVASTPTTVSDGENKKDK

Database cross reference

RefSeq Protein accession:NP_001137484
RefSeq Protein gi:221136993

HLPP validation

Yes/No

Yes

Project name

Chinese Liver;French Liver;Human Liver Organelles;

GO:0016021;C:integral to membrane;IEA:UniProtKB-KW.

GO-P

GO:0045454;P:cell redox homeostasis;IEA:InterPro.

MOD type1

Position1

Residue1

Source name1

source ID1

Source method

HLPP validation1 (Yes/no)

Quality score

HuLPr47343

PHOSPHORYLATION

243

S

PhosphoSitePlus

4775805

LTP

N

HuLPr47343

PHOSPHORYLATION

288

S

PhosphoSitePlus

3216969

LTP

N

HuLPr47343

PHOSPHORYLATION

285

T

PhosphoSitePlus

3216972

LTP

N