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Protein basic information

LiverAtlas Protein ID

HuLPr47409

Uniprot ID

TOIP1_HUMAN

Uniprot Acc

Q5JTV8;A8K630;B0QZ57;Q5JTV6;Q8IZ65;Q9H8Y6;Q9HAJ1;Q9NV52;Q9Y3X5;

Protein name

Torsin-1A-interacting protein 1

Comment

FUNCTION:Binds to A- and B-type lamins. Possible role in membrane attachment and assembly of the nuclear lamina (By similarity).||SUBUNIT:Interacts with ATP1B4 (By similarity). Interacts with TOR1A.||SUBCELLULAR LOCATION:Nucleus inner membrane; Single-pass membrane protein (By similarity).||ALTERNATIVE PRODUCTS:Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q5JTV8-1; Sequence=Displayed; Name=2; IsoId=Q5JTV8-2; Sequence=VSP 017710; Note=No experimental confirmation available;||PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.||SIMILARITY:Belongs to the TOR1AIP family.||SEQUENCE CAUTION:Sequence=AAH23247.1; Type=Erroneous initiation; Sequence=BAB13855.1; Type=Erroneous initiation; Sequence=BAB14461.1; Type=Erroneous initiation; Sequence=BAF84184.1; Type=Erroneous initiation;

Subcellular localization

Nucleus inner membrane;Single-pass membrane protein(By similarity).

Gene name

torsin A interacting protein 1

Protein sequence

MAGDGRRAEAVREGWGVYVTPRAPIREGRGRLAPQNGGSS DAPAYRTPPSRQGRREVRFSDEPPEVYGDFEPLVAKERS PVGKRTRLEEFRSDSAKEEVRESAYYLRSRQRRQPRPQE TEEMKTRRTTRLQQQHSEQPPLQPSPVMTRRGLRDSHSS EEDEASSQTDLSQTISKKTVRSIQEAPVSEDLVIRLRRP PLRYPRYEATSVQQKVNFSEEGETEEDDQDSSHSSVTTV KARSRDSDESGDKTTRSSSQYIESFWQSSQSQNFTAHDK QPSVLSSGYQKTPQEWAPQTARIRTRMQNDSILKSELGN QSPSTSSRQVTGQPQNASFVKRNRWWLLPLIAALASGSF WFFSTPEVETTAVQEFQNQMNQLKNKYQGQDEKLWKRSQ TFLEKHLNSSHPRSQPAILLLTAARDAEEALRCLSEQIA DAYSSFRSVRAIRIDGTDKATQDSDTVKLEVDQELSNGF KNGQNAAVVHRFESFPAGSTLIFYKYCDHENAAFKDVAL VLTVLLEEETLGTSLGLKEVEEKVRDFLKVKFTNSNTPN SYNHMDPDKLNGLWSRISHLVLPVQPENALKRGICL

Database cross reference

RefSeq Protein accession:NP_056417
RefSeq Protein gi:39753957

Ontology annotation

GO-C

GO:0016021;C:integral to membrane;IEA:UniProtKB-KW. GO:0005637;C:nuclear inner membrane;IEA:UniProtKB-SubCell.

Post-translational modification

LiverAtlas Protein ID

MOD type1

Position1

Residue1

Source name1

source ID1

Source method

HLPP validation1 (Yes/no)

Quality score

HuLPr47409

PHOSPHORYLATION

135

S

Phospho-ELM

35746

HTP

N

HuLPr47409

PHOSPHORYLATION

143

S

Phospho-ELM

12419

HTP

N

HuLPr47409

PHOSPHORYLATION

154

S

Phospho-ELM

12420

HTP

N

HuLPr47409

PHOSPHORYLATION

156

S

Phospho-ELM

13534

HTP

N

HuLPr47409

PHOSPHORYLATION

157

S

Phospho-ELM

13535

HTP

N

HuLPr47409

PHOSPHORYLATION

163

S

Phospho-ELM

12421

HTP

N

HuLPr47409

PHOSPHORYLATION

164

S

Phospho-ELM

13536

HTP

N

HuLPr47409

PHOSPHORYLATION

166

T

Phospho-ELM

35752

HTP

N

HuLPr47409

PHOSPHORYLATION

169

S

Phospho-ELM

20266

HTP

N

HuLPr47409

PHOSPHORYLATION

186

S

Phospho-ELM

35747

HTP

N

HuLPr47409

PHOSPHORYLATION

215

S

Phospho-ELM

35748

HTP

N

HuLPr47409

PHOSPHORYLATION

220

T

Phospho-ELM

13537

HTP

N

HuLPr47409

PHOSPHORYLATION

266

S

Phospho-ELM

20267

HTP

N

HuLPr47409

PHOSPHORYLATION

305

S

Phospho-ELM

35749

HTP

N

HuLPr47409

PHOSPHORYLATION

315

S

Phospho-ELM

35750

HTP

N

HuLPr47409

PHOSPHORYLATION

317

S

Phospho-ELM

35751

HTP

N

HuLPr47409

PHOSPHORYLATION

227

S

PhosphoSitePlus

12201600

LTP

N

HuLPr47409

PHOSPHORYLATION

50

S

PhosphoSitePlus

14703154

HTP

N

HuLPr47409

PHOSPHORYLATION

60

S

PhosphoSitePlus

484527

LTP

HTP

N

HuLPr47409

PHOSPHORYLATION

254

S

PhosphoSitePlus

482595

LTP

N

HuLPr47409

PHOSPHORYLATION

266

S

PhosphoSitePlus

482596

LTP

N

HuLPr47409

PHOSPHORYLATION

228

S

PhosphoSitePlus

14161529

LTP

HTP

N

HuLPr47409

PHOSPHORYLATION

147

T

PhosphoSitePlus

9426431

LTP

N

HuLPr47409

PHOSPHORYLATION

220

T

PhosphoSitePlus

471663

LTP

N

HuLPr47409

PHOSPHORYLATION

154

S

PhosphoSitePlus

469772

HTP

N

HuLPr47409

PHOSPHORYLATION

156

S

PhosphoSitePlus

469773

LTP

N

HuLPr47409

PHOSPHORYLATION

157

S

PhosphoSitePlus

469774

LTP

N

HuLPr47409

PHOSPHORYLATION

135

S

PhosphoSitePlus

3198368

LTP

N

HuLPr47409

PHOSPHORYLATION

143

S

PhosphoSitePlus

3198371

LTP

HTP

N

HuLPr47409

PHOSPHORYLATION

163

S

PhosphoSitePlus

3198374

HTP

N

HuLPr47409

PHOSPHORYLATION

186

S

PhosphoSitePlus

3198377

HTP

N

HuLPr47409

PHOSPHORYLATION

215

S

PhosphoSitePlus

3198380

LTP

HTP

N

HuLPr47409

PHOSPHORYLATION

305

S

PhosphoSitePlus

3198383

LTP

N

HuLPr47409

PHOSPHORYLATION

315

S

PhosphoSitePlus

3198386

LTP

HTP

N

HuLPr47409

PHOSPHORYLATION

317

S

PhosphoSitePlus

3198389

LTP

N

HuLPr47409

PHOSPHORYLATION

166

T

PhosphoSitePlus

3198392

HTP

N

HuLPr47409

PHOSPHORYLATION

164

S

PhosphoSitePlus

481954

LTP

N

HuLPr47409

PHOSPHORYLATION

169

S

PhosphoSitePlus

481955

LTP

N