HuLPr47439

Uniprot ID

TOX3_HUMAN

Uniprot Acc

O15405;

Protein name

TOX high mobility group box family member 3

Comment

FUNCTION:Transcriptional coactivator of the p300/CBP-mediated trancription complex. Activates transactivation through cAMP response element (CRE) sites. Protects against cell death by inducing antiapoptotic and repressing pro-apoptotic transcripts. Stimulates transcription from the estrogen-responsive or BCL-2 promoters. Required for depolarization-induced transcription activation of the C-FOS promoter in neurons. Associates with chromatin to the estrogen-responsive C3 promoter region.||SUBUNIT:Homodimer. Interacts with CREB1; the interaction is not depolarization dependent. Interacts with CREBBP (via C-terminus) (By similarity). Interacts (via HGM box) with CITED1 (via C- terminus); the interaction increases estrogen-response element (ERE)-dependent transcription and protection against cell death. Interacts with CREB1 (phosporylated form).||SUBCELLULAR LOCATION:Nucleus (Probable).||TISSUE SPECIFICITY:Expressed mainly in epithelial cells. Expressed in the central nervous system (CNS),

Subcellular localization

Nucleus(Probable).

Gene name

TOX high mobility group box family member 3

Protein sequence

MDVRFYPAAAGDPASLDFAQCLGYYGYSKFGNNNNYMNMA EANNAFFAASEQTFHTPSLGDEEFEIPPITPPPESDPAL GMPDVLLPFQALSDPLPSQGSEFTPQFPPQSLDLPSITI SRNLVEQDGVLHSSGLHMDQSHTQVSQYRQDPSLIMRSI VHMTDAARSGVMPPAQLTTINQSQLSAQLGLNLGGASMP HTSPSPPASKSATPSPSSSINEEDADEANRAIGEKRAAP DSGKKPKTPKKKKKKDPNEPQKPVSAYALFFRDTQAAIK GQNPNATFGEVSKIVASMWDSLGEEQKQVYKRKTEAAKK EYLKALAAYRASLVSKAAAESAEAQTIRSVQQTLASTNL TSSLLLNTPLSQHGTVSASPQTLQQSLPRSIAPKPLTMR LPMNQIVTSVTIAANMPSNIGAPLISSMGTTMVGSAPST QVSPSVQTQQHQMQLQQQQQQQQQQMQQMQQQQLQQHQM HQQIQQQMQQQHFQHHMQQHLQQQQQHLQQQINQQQLQQ QLQQRLQLQQLQHMQHQSQPSPRQHSPVASQITSPIPAI GSPQPASQQHQSQIQSQTQTQVLSQVSIF

Database cross reference

RefSeq Protein accession:NP_001073899
RefSeq Protein gi:226054295

HLPP validation

Yes/No

Yes

Project name

Chinese Liver;French Liver;

GO:0005634;C:nucleus;IEA:UniProtKB-SubCell.

GO-F

GO:0003682;F:chromatin binding;IDA:UniProtKB. GO:0034056;F:estrogen response element binding;IDA:UniProtKB. GO:0051219;F:phosphoprotein binding;IPI:UniProtKB. GO:0042803;F:protein homodimerization activity;IDA:UniProtKB. GO:0016563;F:transcription acti

GO-P

GO:0043524;P:negative regulation of neuron apoptosis;IDA:UniProtKB. GO:0045768;P:positive regulation of anti-apoptosis;IDA:UniProtKB.