HuLPr47455

Uniprot ID

TPC2L_HUMAN

Uniprot Acc

Q9UL33;B2R4M9;Q6ZTA7;Q9NZZ4;

Protein name

Trafficking protein particle complex subunit 2-like protein

Comment

FUNCTION:May play a role in vesicular transport from endoplasmic reticulum to Golgi.||SUBUNIT:Part of the multisubunit TRAPP (transport protein particle) complex. Interacts with the heterodimer TRAPPC3- TRAPPC6A. Interacts with TRAPPC2, TRAPPC3, TRAPPC4 and TRAPPC6A.||SUBCELLULAR LOCATION:Cytoplasm, perinuclear region. Endoplasmic reticulum. Golgi apparatus.||ALTERNATIVE PRODUCTS:Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9UL33-1; Sequence=Displayed; Name=2; IsoId=Q9UL33-2; Sequence=VSP 026641;||TISSUE SPECIFICITY:Expressed in testis, liver, bladder, lung, spleen and brain, several cell lines and primary chondrocytes cell line.||SIMILARITY:Belongs to the TRAPP small subunits family. Sedlin subfamily.||SEQUENCE CAUTION:Sequence=BAC86686.1; Type=Miscellaneous discrepancy; Note=Intron retention;

Subcellular localization

Cytoplasm, perinuclear region.Endoplasmic reticulum.Golgi apparatus.

Gene name

trafficking protein particle complex 2-like

Protein sequence

MAVCIAVIAKENYPLYIRSTPTENELKFHYMVHTSLDVVD EKISAMGKALVDQRELYLGLLYPTEDYKVYGYVTNSKVK FVMVVDSSNTALRDNEIRSMFRKLHNSYTDVMCNPFYNP GDRIQSSRAFDNMVTSMMIQVC

Database cross reference

RefSeq Protein accession:NP_057293
RefSeq Protein gi:7706429

HLPP validation

Yes/No

Yes

Project name

Chinese Liver;

GO:0005783;C:endoplasmic reticulum;IEA:UniProtKB-SubCell. GO:0005794;C:Golgi apparatus;IEA:UniProtKB-SubCell. GO:0048471;C:perinuclear region of cytoplasm;IEA:UniProtKB-SubCell.

GO-P

GO:0006888;P:ER to Golgi vesicle-mediated transport;IEA:InterPro.