HuLPr47499

Uniprot ID

TPST2_HUMAN

Uniprot Acc

O60704;B3KQA7;Q6FI98;Q9H0V4;

Protein name

Protein-tyrosine sulfotransferase 2

Comment

FUNCTION:Catalyzes the O-sulfation of tyrosine residues within acidic motifs of polypeptides.||CATALYTIC ACTIVITY:3'-phosphoadenylyl sulfate + protein tyrosine = adenosine 3',5'-bisphosphate + protein tyrosine-O-sulfate.||SUBCELLULAR LOCATION:Golgi apparatus membrane; Single-pass type II membrane protein (By similarity).||TISSUE SPECIFICITY:Widely expressed.||SIMILARITY:Belongs to the protein sulfotransferase family.

Subcellular localization

Golgi apparatus membrane;Single-pass type II membrane protein(By similarity).

Gene name

tyrosylprotein sulfotransferase 2

Protein sequence

MRLSVRRVLLAAGCALVLVLAVQLGQQVLECRAVLAGLRS PRGAMRPEQEELVMVGTNHVEYRYGKAMPLIFVGGVPRS GTTLMRAMLDAHPEVRCGEETRIIPRVLAMRQAWSKSGR EKLRLDEAGVTDEVLDAAMQAFILEVIAKHGEPARVLCN KDPFTLKSSVYLSRLFPNSKFLLMVRDGRASVHSMITRK VTIAGFDLSSYRDCLTKWNKAIEVMYAQCMEVGKEKCLP VYYEQLVLHPRRSLKLILDFLGIAWSDAVLHHEDLIGKP GGVSLSKIERSTDQVIKPVNLEALSKWTGHIPGDVVRDM AQIAPMLAQLGYDPYANPPNYGNPDPFVINNTQRVLKGD YKTPANLKGYFQVNQNSTSSHLGSS

Database cross reference

RefSeq Protein accession:NP_001008566
RefSeq Protein gi:56699465

GO:0005783;C:endoplasmic reticulum;IDA:LIFEdb. GO:0000139;C:Golgi membrane;IEA:UniProtKB-SubCell. GO:0016021;C:integral to membrane;IEA:UniProtKB-KW. GO:0005624;C:membrane fraction;TAS:ProtInc.

GO-F

GO:0008476;F:protein-tyrosine sulfotransferase activity;TAS:ProtInc.

GO-P

GO:0006478;P:peptidyl-tyrosine sulfation;TAS:ProtInc.

IL2