Protein basic information
| LiverAtlas Protein ID |
HuLPr47501 |
|
Uniprot ID |
|
|
Uniprot Acc |
Q6XPS3;B1AQ16;Q5VUH2;Q8WWL4;Q8WWL5; |
|
Protein name |
Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase TPTE2 |
|
Comment |
CATALYTIC ACTIVITY:Phosphatidylinositol 3,4,5-trisphosphate + H(2)O = phosphatidylinositol 4,5-bisphosphate + phosphate.||SUBCELLULAR LOCATION:Endoplasmic reticulum membrane; Multi-pass membrane protein.||SUBCELLULAR LOCATION:Isoform 4:Cytoplasm.||ALTERNATIVE PRODUCTS:Event=Alternative splicing; Named isoforms=4; Name=1; Synonyms=TPIP gamma; IsoId=Q6XPS3-1; Sequence=Displayed; Name=2; IsoId=Q6XPS3-2; Sequence=VSP 017324; Name=3; Synonyms=TPIP alpha; IsoId=Q6XPS3-3; Sequence=VSP 017323, VSP 017324; Name=4; Synonyms=TPIP beta; IsoId=Q6XPS3-4; Sequence=VSP 017322, VSP 017325;||TISSUE SPECIFICITY:Isoform 3 is expressed in testis, brain and stomach while isoform 4 seems to be testis-specific.||SIMILARITY:Contains 1 C2 tensin-type domain.||SIMILARITY:Contains 1 phosphatase tensin-type domain. |
|
Subcellular localization |
Endoplasmic reticulum membrane;Multi-pass membrane protein. |
|
Gene name |
transmembrane phosphoinositide 3-phosphatase and tensin homolog 2 |
|
Protein sequence
|
MNESPQTNEFKGTTEEAPAKESPHTSEFKGAALVSPISKS MLERLSKFEVEDAENVASYDSKIKKIVHSIVSSFAFGIF GVFLVLLDVTLLLADLIFTDSKLYIPLEYRSISLAIGLF FLMDVLLRVFVEGRQQYFSDLFNILDTAIIVIPLLVDVI YIFFDIKLLRNIPRWTHLVRLLRLIILIRIFHLLHQKRQ LEKLMRRLVSENKRRYTRDGFDLDLTYVTERIIAMSFPS SGRQSFYRNPIEEVVRFLDKKHRNHYRVYNLCSERAYDP KHFHNRVSRIMIDDHNVPTLHEMVVFTKEVNEWMAQDLE NIVAIHCKGGKGRTGTMVCALLIASEIFLTAEESLYYFG ERRTNKTHSNKFQGVETPSQNRYVGYFAQVKHLYNWNLP PRRILFIKRFIIYSIRGDVCDLKVQVVMEKKVVFSSTSL GNCSILHDIETDKILINVYDGPPLYDDVKVQFFSSNLPK YYDNCPFFFWFNTSFIQNNRLCLPRNELDNPHKQKAWKI YPPEFAVEILFGEK |
|
Database cross reference |
RefSeq Protein accession:NP_001135440
|
Ontology annotation
| GO-C |
GO:0005789;C:endoplasmic reticulum membrane;IEA:UniProtKB-SubCell. GO:0016021;C:integral to membrane;IEA:UniProtKB-KW. |
|
GO-F |
GO:0005216;F:ion channel activity;IEA:InterPro. GO:0016314;F:phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity;IEA:EC. GO:0004725;F:protein tyrosine phosphatase activity;IEA:InterPro. GO:0008138;F:protein tyrosine/serine/threonine phosphat |
Post-translational modification
| LiverAtlas Protein ID |
MOD type1 |
Position1 |
Residue1 |
Source name1 |
source ID1 |
Source method |
HLPP validation1 (Yes/no) |
Quality score |
|
HuLPr47501 |
PHOSPHORYLATION |
404 |
Y |
PhosphoSitePlus |
LTP |
N |
 
|
