Protein basic information
LiverAtlas Protein ID |
HuLPr47520 |
Uniprot ID |
|
Uniprot Acc |
O14545;A8K5L6; |
Protein name |
TRAF-type zinc finger domain-containing protein 1 |
Comment |
FUNCTION:Negative feedback regulator that controls excessive innate immune responses. Regulates both Toll-like receptor 4 (TLR4) and DDX58/RIG1-like helicases (RLH) pathways. May inhibit the LTR pathway by direct interaction with TRAF6 and attenuation of NF-kappa-B activation. May negatively regulate the RLH pathway downstream from MAVS and upstream of NF-kappa-B and IRF3 (By similarity).||SUBUNIT:Interacts with MAVS, TICAM1, TRAF1, TRAF2, TRAF3 (By similarity). Interacts with TRAF6.||INTERACTION:Q9Y4K3:TRAF6; NbExp=1; IntAct=EBI-1396921, EBI-359276; P70196:Traf6 (xeno); NbExp=1; IntAct=EBI-1396921, EBI-448028;||SIMILARITY:Contains 1 TRAF-type zinc finger. |
Gene name |
|
Protein sequence
|
MAEFLDDQETRLCDNCKKEIPVFNFTIHEIHCQRNIGMCP TCKEPFPKSDMETHMAAEHCQVTCKCNKKLEKRLLKKHE ETECPLRLAVCQHCDLELSILKLKEHEDYCGARTELCGN CGRNVLVKDLKTHPEVCGREGEEKRNEVAIPPNAYDESW GQDGIWIASQLLRQIEALDPPMRLPRRPLRAFESDVFHN RTTNQRNITAQVSIQNNLFEEQERQERNRGQQPPKEGGE ESANLDFMLALSLQNEGQASSVAEQDFWRAVCEADQSHG GPRSLSDIKGAADEIMLPCEFCEELYPEELLIDHQTSCN PSRALPSLNTGSSSPRGVEEPDVIFQNFLQQAASNQLDS LMGLSNSHPVEESIIIPCEFCGVQLEEEVLFHHQDQCDQ RPATATNHVTEGIPRLDSQPQETSPELPRRRVRHQGDLS SGYLDDTKQETANGPTSCLPPSRPINNMTATYNQLSRST SGPRPGCQPSSPCVPKLSNSDSQDIQGRNRDSQNGAIAP GHVSVIRPPQNLYPENIVPSFSPGPSGRYGASGRSEGGR NSRVTPAAANYRSRTAKAKPSKQQGAGDAEEEEEE |
Database cross reference |
RefSeq Protein accession:NP_001137378
|
Liver relevance
HLPP validation |
Yes/No |
Yes |
Project name |
Human Liver Organelles; |
Ontology annotation
GO-C |
GO:0005622;C:intracellular;IEA:InterPro. |
GO-F |
GO:0005515;F:protein binding;IPI:IntAct. GO:0008270;F:zinc ion binding;IEA:InterPro. |
GO-P |
GO:0045824;P:negative regulation of innate immune response;ISS:UniProtKB. |
Post-translational modification
LiverAtlas Protein ID |
MOD type1 |
Position1 |
Residue1 |
Source name1 |
source ID1 |
Source method |
HLPP validation1 (Yes/no) |
Quality score |
HuLPr47520 |
PHOSPHORYLATION |
415 |
S |
Phospho-ELM |
HTP |
N |
||
HuLPr47520 |
PHOSPHORYLATION |
326 |
S |
Phospho-ELM |
HTP |
N |
||
HuLPr47520 |
PHOSPHORYLATION |
327 |
S |
Phospho-ELM |
HTP |
N |
||
HuLPr47520 |
PHOSPHORYLATION |
414 |
T |
Phospho-ELM |
HTP |
N |
||
HuLPr47520 |
PHOSPHORYLATION |
470 |
S |
Phospho-ELM |
HTP |
N |
||
HuLPr47520 |
PHOSPHORYLATION |
530 |
S |
Phospho-ELM |
HTP |
N |
||
HuLPr47520 |
PHOSPHORYLATION |
470 |
S |
PhosphoSitePlus |
LTP |
N |
||
HuLPr47520 |
PHOSPHORYLATION |
479 |
S |
PhosphoSitePlus |
LTP |
N |
||
HuLPr47520 |
PHOSPHORYLATION |
415 |
S |
PhosphoSitePlus |
LTP |
N |
||
HuLPr47520 |
PHOSPHORYLATION |
326 |
S |
PhosphoSitePlus |
HTP |
N |
||
HuLPr47520 |
PHOSPHORYLATION |
327 |
S |
PhosphoSitePlus |
HTP |
N |
||
HuLPr47520 |
PHOSPHORYLATION |
323 |
T |
PhosphoSitePlus |
LTP HTP |
N |
||
HuLPr47520 |
PHOSPHORYLATION |
414 |
T |
PhosphoSitePlus |
LTP |
N |
||
HuLPr47520 |
PHOSPHORYLATION |
325 |
S |
PhosphoSitePlus |
LTP |
N |
Pathway
Pathway name |