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Protein basic information

LiverAtlas Protein ID

HuLPr47520

Uniprot ID

TRAD1_HUMAN

Uniprot Acc

O14545;A8K5L6;

Protein name

TRAF-type zinc finger domain-containing protein 1

Comment

FUNCTION:Negative feedback regulator that controls excessive innate immune responses. Regulates both Toll-like receptor 4 (TLR4) and DDX58/RIG1-like helicases (RLH) pathways. May inhibit the LTR pathway by direct interaction with TRAF6 and attenuation of NF-kappa-B activation. May negatively regulate the RLH pathway downstream from MAVS and upstream of NF-kappa-B and IRF3 (By similarity).||SUBUNIT:Interacts with MAVS, TICAM1, TRAF1, TRAF2, TRAF3 (By similarity). Interacts with TRAF6.||INTERACTION:Q9Y4K3:TRAF6; NbExp=1; IntAct=EBI-1396921, EBI-359276; P70196:Traf6 (xeno); NbExp=1; IntAct=EBI-1396921, EBI-448028;||SIMILARITY:Contains 1 TRAF-type zinc finger.

Gene name

TRAF-type zinc finger domain containing 1

Protein sequence

MAEFLDDQETRLCDNCKKEIPVFNFTIHEIHCQRNIGMCP TCKEPFPKSDMETHMAAEHCQVTCKCNKKLEKRLLKKHE ETECPLRLAVCQHCDLELSILKLKEHEDYCGARTELCGN CGRNVLVKDLKTHPEVCGREGEEKRNEVAIPPNAYDESW GQDGIWIASQLLRQIEALDPPMRLPRRPLRAFESDVFHN RTTNQRNITAQVSIQNNLFEEQERQERNRGQQPPKEGGE ESANLDFMLALSLQNEGQASSVAEQDFWRAVCEADQSHG GPRSLSDIKGAADEIMLPCEFCEELYPEELLIDHQTSCN PSRALPSLNTGSSSPRGVEEPDVIFQNFLQQAASNQLDS LMGLSNSHPVEESIIIPCEFCGVQLEEEVLFHHQDQCDQ RPATATNHVTEGIPRLDSQPQETSPELPRRRVRHQGDLS SGYLDDTKQETANGPTSCLPPSRPINNMTATYNQLSRST SGPRPGCQPSSPCVPKLSNSDSQDIQGRNRDSQNGAIAP GHVSVIRPPQNLYPENIVPSFSPGPSGRYGASGRSEGGR NSRVTPAAANYRSRTAKAKPSKQQGAGDAEEEEEE

Database cross reference

RefSeq Protein accession:NP_001137378
RefSeq Protein gi:219879806

Liver relevance

HLPP validation

Yes/No

Yes

Project name

Human Liver Organelles;

Ontology annotation

GO-C

GO:0005622;C:intracellular;IEA:InterPro.

GO-F

GO:0005515;F:protein binding;IPI:IntAct. GO:0008270;F:zinc ion binding;IEA:InterPro.

GO-P

GO:0045824;P:negative regulation of innate immune response;ISS:UniProtKB.

Post-translational modification

LiverAtlas Protein ID

MOD type1

Position1

Residue1

Source name1

source ID1

Source method

HLPP validation1 (Yes/no)

Quality score

HuLPr47520

PHOSPHORYLATION

415

S

Phospho-ELM

5966

HTP

N

HuLPr47520

PHOSPHORYLATION

326

S

Phospho-ELM

31565

HTP

N

HuLPr47520

PHOSPHORYLATION

327

S

Phospho-ELM

10993

HTP

N

HuLPr47520

PHOSPHORYLATION

414

T

Phospho-ELM

31568

HTP

N

HuLPr47520

PHOSPHORYLATION

470

S

Phospho-ELM

31566

HTP

N

HuLPr47520

PHOSPHORYLATION

530

S

Phospho-ELM

31567

HTP

N

HuLPr47520

PHOSPHORYLATION

470

S

PhosphoSitePlus

483093

LTP

N

HuLPr47520

PHOSPHORYLATION

479

S

PhosphoSitePlus

483094

LTP

N

HuLPr47520

PHOSPHORYLATION

415

S

PhosphoSitePlus

449166

LTP

N

HuLPr47520

PHOSPHORYLATION

326

S

PhosphoSitePlus

3174521

HTP

N

HuLPr47520

PHOSPHORYLATION

327

S

PhosphoSitePlus

483530

HTP

N

HuLPr47520

PHOSPHORYLATION

323

T

PhosphoSitePlus

2525337

LTP

HTP

N

HuLPr47520

PHOSPHORYLATION

414

T

PhosphoSitePlus

2525340

LTP

N

HuLPr47520

PHOSPHORYLATION

325

S

PhosphoSitePlus

4269835

LTP

N

Pathway

Pathway name

IL2