HuLPr47563

Uniprot ID

TRI23_HUMAN

Uniprot Acc

P36406;Q9BZY4;Q9BZY5;

Protein name

E3 ubiquitin-protein ligase TRIM23

Comment

FUNCTION:Acts as an E3 ubiquitin-protein ligase. In the presence of the human cytomegalovirus (HCMV) protein UL144, participates in 'Lys-63'-linked auto-ubiquitination of TRAF6 resulting in the virally controlled activation of NF-kappa-B at early time of infection. The C-terminus can act as an allosteric activator of the cholera toxin catalytic subunit.||PATHWAY:Protein modification; protein ubiquitination.||SUBUNIT:Interacts with PSCD1. Interacts with human cytomegalovirus protein UL144 in a complex containing TRAF6.||INTERACTION:P55040:GEM; NbExp=2; IntAct=EBI-740098, EBI-744104;||SUBCELLULAR LOCATION:Endomembrane system. Golgi apparatus membrane. Lysosome membrane. Note=Membrane-associated with the Golgi complex and lysosomal structures.||ALTERNATIVE PRODUCTS:Event=Alternative splicing; Named isoforms=3; Name=Alpha; IsoId=P36406-1; Sequence=Displayed; Name=Beta; IsoId=P36406-2; Sequence=VSP 000296; Name=Gamma; IsoId=P36406-3; Sequence=VSP 000297;||DOMAIN:The RING-type zinc fin

Subcellular localization

Endomembrane system.Golgi apparatus membrane.Lysosome membrane.

Gene name

tripartite motif containing 23

Protein sequence

MATLVVNKLGAGVDSGRQGSRGTAVVKVLECGVCEDVFSL QGDKVPRLLLCGHTVCHDCLTRLPLHGRAIRCPFDRQVT DLGDSGVWGLKKNFALLELLERLQNGPIGQYGAAEESIG ISGESIIRCDEDEAHLASVYCTVCATHLCSECSQVTHST KTLAKHRRVPLADKPHEKTMCSQHQVHAIEFVCLEEGCQ TSPLMCCVCKEYGKHQGHKHSVLEPEANQIRASILDMAH CIRTFTEEISDYSRKLVGIVQHIEGGEQIVEDGIGMAHT EHVPGTAENARSCIRAYFYDLHETLCRQEEMALSVVDAH VREKLIWLRQQQEDMTILLSEVSAACLHCEKTLQQDDCR VVLAKQEITRLLETLQKQQQQFTEVADHIQLDASIPVTF TKDNRVHIGPKMEIRVVTLGLDGAGKTTILFKLKQDEFM QPIPTIGFNVETVEYKNLKFTIWDVGGKHKLRPLWKHYY LNTQAVVFVVDSSHRDRISEAHSELAKLLTEKELRDALL LIFANKQDVAGALSVEEITELLSLHKLCCGRSWYIQGCD ARSGMGLYEGLDWLSRQLVAAGVLDVA

Database cross reference

RefSeq Protein accession:NP_001647
RefSeq Protein gi:4502197

HLPP validation

Yes/No

Yes

Project name

Human Liver Organelles;

GO:0000139;C:Golgi membrane;IDA:HGNC. GO:0005765;C:lysosomal membrane;IDA:HGNC.

GO-F

GO:0008047;F:enzyme activator activity;TAS:ProtInc. GO:0019003;F:GDP binding;IDA:HGNC. GO:0005525;F:GTP binding;IDA:HGNC. GO:0003924;F:GTPase activity;IDA:HGNC. GO:0005515;F:protein binding;IPI:IntAct. GO:0004842;F:ubiquitin-protein ligase activity;ID

GO-P

GO:0044419;P:interspecies interaction between organisms;IEA:UniProtKB-KW. GO:0007264;P:small GTPase mediated signal transduction;IEA:InterPro.

MOD type1

Position1

Residue1

Source name1

source ID1

Source method

HLPP validation1 (Yes/no)

Quality score

HuLPr47563

PHOSPHORYLATION

468

Y

PhosphoSitePlus

990466

LTP

N

HuLPr47563

PHOSPHORYLATION

469

Y

PhosphoSitePlus

990470

LTP

HTP

N