Protein basic information
| LiverAtlas Protein ID |
HuLPr47607 |
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Uniprot ID |
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Uniprot Acc |
Q92519;B2R851;D6W510; |
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Protein name |
Tribbles homolog 2 |
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Comment |
FUNCTION:Interacts with MAPK kinases and regulates activation of MAP kinases. Does not display kinase activity (By similarity).||SUBCELLULAR LOCATION:Cytoplasm (By similarity). Cytoplasm, cytoskeleton (By similarity). Note=May associate with the cytoskeleton (By similarity).||TISSUE SPECIFICITY:Highly expressed in peripheral blood leukocytes.||MISCELLANEOUS:Antibodies against TRIB2 are present in sera from patients with autoimmune uveitis.||SIMILARITY:Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. Tribbles subfamily.||SIMILARITY:Contains 1 protein kinase domain. |
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Subcellular localization |
Cytoplasm(By similarity).Cytoplasm, cytoskeleton(By similarity). |
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Gene name |
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Protein sequence
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MNIHRSTPITIARYGRSRNKTQDFEELSSIRSAEPSQSFS PNLGSPSPPETPNLSHCVSCIGKYLLLEPLEGDHVFRAV HLHSGEELVCKVFDISCYQESLAPCFCLSAHSNINQITE IILGETKAYVFFERSYGDMHSFVRTCKKLREEEAARLFY QIASAVAHCHDGGLVLRDLKLRKFIFKDEERTRVKLESL EDAYILRGDDDSLSDKHGCPAYVSPEILNTSGSYSGKAA DVWSLGVMLYTMLVGRYPFHDIEPSSLFSKIRRGQFNIP ETLSPKAKCLIRSILRREPSERLTSQEILDHPWFSTDFS VSNSAYGAKEVSDQLVPDVNMEENLDPFFN |
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Database cross reference |
RefSeq Protein accession:NP_067675
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Ontology annotation
| GO-C |
GO:0005737;C:cytoplasm;ISS:UniProtKB. GO:0005856;C:cytoskeleton;IEA:UniProtKB-SubCell. GO:0005634;C:nucleus;IDA:HPA. |
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GO-F |
GO:0005524;F:ATP binding;IEA:InterPro. GO:0004672;F:protein kinase activity;IEA:InterPro. GO:0004860;F:protein kinase inhibitor activity;IEA:UniProtKB-KW. GO:0008134;F:transcription factor binding;ISS:BHF-UCL. GO:0031625;F:ubiquitin protein ligase bind |
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GO-P |
GO:0045599;P:negative regulation of fat cell differentiation;ISS:BHF-UCL. GO:0045081;P:negative regulation of interleukin-10 biosynthetic process;IMP:BHF-UCL. GO:0006469;P:negative regulation of protein kinase activity;NAS:BHF-UCL. GO:0032436;P:positive |
Post-translational modification
| LiverAtlas Protein ID |
MOD type1 |
Position1 |
Residue1 |
Source name1 |
source ID1 |
Source method |
HLPP validation1 (Yes/no) |
Quality score |
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HuLPr47607 |
PHOSPHORYLATION |
14 |
Y |
PhosphoSitePlus |
LTP |
N |
 
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Pathway
| Pathway name | |
| Pathway name |
