HuLPr47646

Uniprot ID

TRPA1_HUMAN

Uniprot Acc

O75762;A6NIN6;

Protein name

Transient receptor potential cation channel subfamily A member 1

Comment

FUNCTION:Receptor-activated non-selective cation channel involved in detection of pain and possibly also in cold perception and inner ear function. Has a central role in the pain response to endogenous inflammatory mediators and to a diverse array of volatile irritants, such as mustard oil, garlic and acrolein, an irritant from tears gas and vehicule exhaust fumes. Acts also as a ionotropic cannabinoid receptor by being activated by delta(9)- tetrahydrocannabinol (THC), the psychoactive component of marijuana. Not involved in menthol sensation. May be a component for the mechanosensitive transduction channel of hair cells in inner ear, thereby participating in the perception of sounds. Probably operated by a phosphatidylinositol second messenger system (By similarity).||ENZYME REGULATION:Inhibited by ruthenium red, a potent blocker of TRPV channels (By similarity).||SUBCELLULAR LOCATION:Membrane; Multi-pass membrane protein (Probable).||TISSUE SPECIFICITY:Expressed at very low level. E

Subcellular localization

Membrane;Multi-pass membrane protein(Probable).

Gene name

transient receptor potential cation channel, subfamily A, member 1

Protein sequence

MKRSLRKMWRPGEKKEPQGVVYEDVPDDTEDFKESLKVVF EGSAYGLQNFNKQKKLKRCDDMDTFFLHYAAAEGQIELM EKITRDSSLEVLHEMDDYGNTPLHCAVEKNQIESVKFLL SRGANPNLRNFNMMAPLHIAVQGMNNEVMKVLLEHRTID VNLEGENGNTAVIIACTTNNSEALQILLKKGAKPCKSNK WGCFPIHQAAFSGSKECMEIILRFGEEHGYSRQLHINFM NNGKATPLHLAVQNGDLEMIKMCLDNGAQIDPVEKGRCT AIHFAATQGATEIVKLMISSYSGSVDIVNTTDGCHETML HRASLFDHHELADYLISVGADINKIDSEGRSPLILATAS ASWNIVNLLLSKGAQVDIKDNFGRNFLHLTVQQPYGLKN LRPEFMQMQQIKELVMDEDNDGCTPLHYACRQGGPGSVN NLLGFNVSIHSKSKDKKSPLHFAASYGRINTCQRLLQDI SDTRLLNEGDLHGMTPLHLAAKNGHDKVVQLLLKKGALF LSDHNGWTALHHASMGGYTQTMKVILDTNLKCTDRLDED GNTALHFAAREGHAKAVALLLSHNADIVLNKQQASFLHL ALHNKRKEVVLTIIRSKRWDECLKIFSHNSPGNKCPITE MIEYLPECMKVLLDFCMLHSTEDKSCRDYYIEYNFKYLQ CPLEFTKKTPTQDVIYEPLTALNAMVQNNRIELLNHPVC KEYLLMKWLAYGFRAHMMNLGSYCLGLIPMTILVVNIKP GMAFNSTGIINETSDHSEILDTTNSYLIKTCMILVFLSS IFGYCKEAGQIFQQKRNYFMDISNVLEWIIYTTGIIFVL PLFVEIPAHLQWQCGAIAVYFYWMNFLLYLQRFENCGIF IVMLEVILKTLLRSTVVFIFLLLAFGLSFYILLNLQDPF SSPLLSIIQTFSMMLGDINYRESFLEPYLRNELAHPVLS FAQLVSFTIFVPIVLMNLLIGLAVGDIAEVQKHASLKRI AMQVELHTSLEKKLPLWFLRKVDQ

Database cross reference

RefSeq Protein accession:NP_015628
RefSeq Protein gi:116534990

HLPP validation

Yes/No

Yes

Project name

Chinese Liver;Human Liver Organelles;

GO:0005887;C:integral to plasma membrane;TAS:ProtInc.