HuLPr47655

Uniprot ID

TRPM3_HUMAN

Uniprot Acc

Q9HCF6;A2A3F6;Q5VW02;Q5VW03;Q5VW04;Q5W5T7;Q86SH0;Q86SH6;Q86UL0;Q86WK1;Q86WK2;Q86WK3;Q86WK4;Q86YZ9;Q86Z00;Q86Z01;Q9H0X2;

Protein name

Transient receptor potential cation channel subfamily M member 3

Comment

FUNCTION:Calcium channel mediating constitutive calcium ion entry. Its activity is increased by reduction in extracellular osmolarity, by store depletion and muscarinic receptor activation.||SUBCELLULAR LOCATION:Membrane; Multi-pass membrane protein.||ALTERNATIVE PRODUCTS:Event=Alternative splicing; Named isoforms=10; Name=1; Synonyms=TRPM3f; IsoId=Q9HCF6-1; Sequence=Displayed; Name=2; Synonyms=TRPM3a; IsoId=Q9HCF6-2; Sequence=VSP 012826; Name=3; Synonyms=TRPM3b; IsoId=Q9HCF6-3; Sequence=VSP 012826, VSP 012828; Name=4; Synonyms=TRPM3d; IsoId=Q9HCF6-4; Sequence=VSP 012826, VSP 012829; Name=5; Synonyms=TRPM3e; IsoId=Q9HCF6-5; Sequence=VSP 012826, VSP 012828, VSP 012829; Name=6; Synonyms=TRPM3c; IsoId=Q9HCF6-6; Sequence=VSP 012826, VSP 012830; Name=7; IsoId=Q9HCF6-7; Sequence=VSP 012829; Name=8; IsoId=Q9HCF6-8; Sequence=VSP 012826, VSP 012827, VSP 012829; Name=10; IsoId=Q9HCF6-10; Sequence=VSP 012826, VSP 012831, VSP 012832; Name=11; IsoId=Q9HCF6-11; Sequence=VSP 03910

Subcellular localization

Membrane;Multi-pass membrane protein.

Gene name

transient receptor potential cation channel, subfamily M, member 3

Protein sequence

MPEPWGTVYFLGIAQVFSFLFSWWNLEGVMNQADAPRPLN WTIRKLCHAAFLPSVRLLKAQKSWIERAFYKRECVHIIP STKDPHRCCCGRLIGQHVGLTPSISVLQNEKNESRLSRN DIQSEKWSISKHTQLSPTDAFGTIEFQGGGHSNKAMYVR VSFDTKPDLLLHLMTKEWQLELPKLLISVHGGLQNFELQ PKLKQVFGKGLIKAAMTTGAWIFTGGVNTGVIRHVGDAL KDHASKSRGKICTIGIAPWGIVENQEDLIGRDVVRPYQT MSNPMSKLTVLNSMHSHFILADNGTTGKYGAEVKLRRQL EKHISLQKINTRCLPFFSLDSRLFYSFWGSCQLDSVGIG QGVPVVALIVEGGPNVISIVLEYLRDTPPVPVVVCDGSG RASDILAFGHKYSEEGGLINESLRDQLLVTIQKTFTYTR TQAQHLFIILMECMKKKELITVFRMGSEGHQDIDLAILT ALLKGANASAPDQLSLALAWNRVDIARSQIFIYGQQWPV GSLEQAMLDALVLDRVDFVKLLIENGVSMHRFLTISRLE ELYNTRHGPSNTLYHLVRDVKKGNLPPDYRISLIDIGLV IEYLMGGAYRCNYTRKRFRTLYHNLFGPKRPKALKLLGM EDDIPLRRGRKTTKKREEEVDIDLDDPEINHFPFPFHEL MVWAVLMKRQKMALFFWQHGEEAMAKALVACKLCKAMAH EASENDMVDDISQELNHNSRDFGQLAVELLDQSYKQDEQ LAMKLLTYELKNWSNATCLQLAVAAKHRDFIAHTCSQML LTDMWMGRLRMRKNSGLKVILGILLPPSILSLEFKNKDD MPYMSQAQEIHLQEKEAEEPEKPTKEKEEEDMELTAMLG RNNGESSRKKDEEEVQSKHRLIPLGRKIYEFYNAPIVKF WFYTLAYIGYLMLFNYIVLVKMERWPSTQEWIVISYIFT LGIEKMREILMSEPGKLLQKVKVWLQEYWNVTDLIAILL FSVGMILRLQDQPFRSDGRVIYCV

Database cross reference

RefSeq Protein accession:NP_001007471
RefSeq Protein gi:55953096

HLPP validation

Yes/No

Yes

Project name

French Liver;Human Liver Organelles;

GO:0016021;C:integral to membrane;IEA:UniProtKB-KW.

GO-F

GO:0005262;F:calcium channel activity;IEA:UniProtKB-KW.