HuLPr47657

Uniprot ID

TRPM5_HUMAN

Uniprot Acc

Q9NZQ8;A6NHS0;Q52LU2;Q9NY34;

Protein name

Transient receptor potential cation channel subfamily M member 5

Comment

FUNCTION:Voltage-modulated Ca(2+)-activated, monovalent cation channel (VCAM) that mediates a transient membrane depolarization and plays a central role in taste transduction. Monovalent- specific, non-selective cation channel that mediates the transport of Na(+), K(+) and Cs(+) ions equally well. Activated directly by increases in intracellular Ca(2+), but is impermeable to it. Gating is voltage-dependent and displays rapid activation and deactivation kinetics upon channel stimulation even during sustained elevations in Ca(2+). Also activated by a fast intracellular Ca(2+) increase in response to inositol 1,4,5- triphosphate-producing receptor agonists. The channel is blocked by extracellular acidification. External acidification has 2 effects, a fast reversible block of the current and a slower irreversible enhancement of current inactivation. Is a highly temperature-sensitive, heat activated channel showing a steep increase of inward currents at temperatures between 15 and 35 degree

Subcellular localization

Cell membrane;Multi-pass membrane protein(Potential).

Gene name

transient receptor potential cation channel, subfamily M, member 5

Protein sequence

MQDVQGPRPGSPGDAEDRRELGLHRGEVNFGGSGKKRGKF VRVPSGVAPSVLFDLLLAEWHLPAPNLVVSLVGEEQPFA MKSWLRDVLRKGLVKAAQSTGAWILTSALRVGLARHVGQ AVRDHSLASTSTKVRVVAVGMASLGRVLHRRILEEAQED FPVHYPEDDGGSQGPLCSLDSNLSHFILVEPGPPGKGDG LTELRLRLEKHISEQRAGYGGTGSIEIPVLCLLVNGDPN TLERISRAVEQAAPWLILVGSGGIADVLAALVNQPHLLV PKVAEKQFKEKFPSKHFSWEDIVRWTKLLQNITSHQHLL TVYDFEQEGSEELDTVILKALVKACKSHSQEPQDYLDEL KLAVAWDRVDIAKSEIFNGDVEWKSCDLEEVMVDALVSN KPEFVRLFVDNGADVADFLTYGRLQELYRSVSRKSLLFD LLQRKQEEARLTLAGLGTQQAREPPAGPPAFSLHEVSRV LKDFLQDACRGFYQDGRPGDRRRAEKGPAKRPTGQKWLL DLNQKSENPWRDLFLWAVLQNRHEMATYFWAMGQEGVAA ALAACKILKEMSHLETEAEAARATREAKYERLALDLFSE CYSNSEARAFALLVRRNRCWSKTTCLHLATEADAKAFFA HDGVQAFLTRIWWGDMAAGTPILRLLGAFLCPALVYTNL ITFSEEAPLRTGLEDLQDLDSLDTEKSPLYGLQSRVEEL VEAPRAQGDRGPRAVFLLTRWRKFWGAPVTVFLGNVVMY FAFLFLFTYVLLVDFRPPPQGPSGPEVTLYFWVFTLVLE EIRQGFFTDEDTHLVKKFTLYVGDNWNKCDMVAIFLFIV GVTCRMLPSAFEAGRTVLAMDFMVFTLRLIHIFAIHKQL GPKIIVVERMMKDVFFFLFFLSVWLVAYGVTTQALLHPH DGRLEWIFRRVLYRPYLQIFGQIPLDEIDEARVNCSTHP LLLEDSPSCPSLYANWLVILLLVTFLLVTNVLLMNLLIA MFSYTFQVVQGNADMFWKFQRYNL

Database cross reference

RefSeq Protein accession:NP_055370
RefSeq Protein gi:11225266

HLPP validation

Yes/No

Yes

Project name

Chinese Liver;French Liver;Human Liver Organelles;

GO:0016021;C:integral to membrane;TAS:ProtInc. GO:0005886;C:plasma membrane;IEA:UniProtKB-SubCell.

GO-F

GO:0004872;F:receptor activity;IEA:UniProtKB-KW. GO:0005244;F:voltage-gated ion channel activity;IEA:UniProtKB-KW.