Protein basic information
| LiverAtlas Protein ID |
HuLPr47662 |
|
Uniprot ID |
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Uniprot Acc |
Q8NER1;A2RUA9;Q9H0G9;Q9H303;Q9H304;Q9NQ74;Q9NY22; |
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Protein name |
Transient receptor potential cation channel subfamily V member 1 |
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Comment |
FUNCTION:Receptor-activated non-selective calcium permeant cation channel involved in detection of noxious chemical and thermal stimuli. Seems to mediate proton influx and may be involved in intracellular acidosis in nociceptive neurons. May be involved in mediation of inflammatory pain and hyperalgesia. Sensitized by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases, which involves PKC isozymes and PCL. Acts as ionotropic endocannabinoid receptor with central neuromodulatory effects. Triggers a form of long-term depression (TRPV1-LTD) mediated by the endocannabinoid anandamine in the hippocampus and nucleus accubens by affecting AMPA receptors endocytosis (By similarity).||ENZYME REGULATION:Channel activity is activated via the interaction with PIRT and phosphatidylinositol-4,5-bisphosphate (PIP2). Both PIRT and PIP2 are required to activate channel activity (By similarity).||SUBUNIT:Self-associates. Probably homotetramer. May also form a heteromeri |
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Subcellular localization |
Cell junction, synapse, postsynaptic cell membrane;Multi-pass membrane protein(By similarity).Cell projection, dendritic spine membrane;Multi-pass membrane protein(By similarity). |
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Gene name |
transient receptor potential cation channel, subfamily V, member 1 |
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Protein sequence
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MKKWSSTDLGAAADPLQKDTCPDPLDGDPNSRPPPAKPQL STAKSRTRLFGKGDSEEAFPVDCPHEEGELDSCPTITVS PVITIQRPGDGPTGARLLSQDSVAASTEKTLRLYDRRSI FEAVAQNNCQDLESLLLFLQKSKKHLTDNEFKDPETGKT CLLKAMLNLHDGQNTTIPLLLEIARQTDSLKELVNASYT DSYYKGQTALHIAIERRNMALVTLLVENGADVQAAAHGD FFKKTKGRPGFYFGELPLSLAACTNQLGIVKFLLQNSWQ TADISARDSVGNTVLHALVEVADNTADNTKFVTSMYNEI LMLGAKLHPTLKLEELTNKKGMTPLALAAGTGKIGVLAY ILQREIQEPECRHLSRKFTEWAYGPVHSSLYDLSCIDTC EKNSVLEVIAYSSSETPNRHDMLLVEPLNRLLQDKWDRF VKRIFYFNFLVYCLYMIIFTMAAYYRPVDGLPPFKMEKT GDYFRVTGEILSVLGGVYFFFRGIQYFLQRRPSMKTLFV DSYSEMLFFLQSLFMLATVVLYFSHLKEYVASMVFSLAL GWTNMLYYTRGFQQMGIYAVMIEKMILRDLCRFMFVYIV FLFGFSTAVVTLIEDGKNDSLPSESTSHRWRGPACRPPD SSYNSLYSTCLELFKFTIGMGDLEFTENYDFKAVFIILL LAYVILTYILLLNMLIALMGETVNKIAQESKNIWKLQRA ITILDTEKSFLKCMRKAFRSGKLLQVGYTPDGKDDYRWC FRVDEVNWTTWNTNVGIINEDPGNCEGVKRTLSFSLRSS RVSGRHWKNFALVPLLREASARDRQSAQPEEVYLRQFSGSLKPEDAEVFKSPAASGEK |
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Database cross reference |
RefSeq Protein accession:NP_061197
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Liver relevance
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HLPP validation |
Yes/No |
Yes |
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Project name |
Chinese Liver;Human Liver Organelles; |
Ontology annotation
| GO-C |
GO:0030054;C:cell junction;IEA:UniProtKB-KW. GO:0032591;C:dendritic spine membrane;IEA:UniProtKB-SubCell. GO:0005887;C:integral to plasma membrane;TAS:ProtInc. GO:0045211;C:postsynaptic membrane;ISS:UniProtKB. |
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GO-F |
GO:0005524;F:ATP binding;IEA:UniProtKB-KW. GO:0005262;F:calcium channel activity;TAS:ProtInc. GO:0005516;F:calmodulin binding;IEA:UniProtKB-KW. |
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GO-P |
GO:0007166;P:cell surface receptor linked signaling pathway;TAS:ProtInc. GO:0007635;P:chemosensory behavior;TAS:ProtInc. GO:0050955;P:thermoception;IDA:MGI. |
Post-translational modification
| LiverAtlas Protein ID |
MOD type1 |
Position1 |
Residue1 |
Source name1 |
source ID1 |
Source method |
HLPP validation1 (Yes/no) |
Quality score |
|
HuLPr47662 |
PHOSPHORYLATION |
502 |
S |
PhosphoSitePlus |
LTP |
N |
 
|
|
|
HuLPr47662 |
PHOSPHORYLATION |
801 |
S |
PhosphoSitePlus |
HTP |
N |
|
|
|
HuLPr47662 |
ACETYLATION |
161 |
K |
PhosphoSitePlus |
HTP |
N |
|
|
|
HuLPr47662 |
PHOSPHORYLATION |
200 |
Y |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr47662 |
PHOSPHORYLATION |
310 |
Y |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr47662 |
PHOSPHORYLATION |
117 |
S |
PhosphoSitePlus |
HTP |
N |
|
Pathway
| Pathway name | |
| Pathway name | |
| Pathway name |
