Protein basic information
| LiverAtlas Protein ID |
HuLPr47663 |
|
Uniprot ID |
|
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Uniprot Acc |
Q9Y5S1;A6NML2;A8K0Z0;Q9Y670; |
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Protein name |
Transient receptor potential cation channel subfamily V member 2 |
|
Comment |
FUNCTION:Calcium-permeable, non-selective cation channel with an outward rectification. Seems to be regulated, at least in part, by IGF-I, PDGF and neuropeptide head activator. May transduce physical stimuli in mast cells. Activated by temperatures higher than 52 degrees Celsius; is not activated by vanilloids and acidic pH.||SUBUNIT:Homotetramer (Probable). Interacts with a cAMP-dependent protein kinase type II regulatory subunit (PRKAR2A or PRKAR2B) and ACBD3. Interacts with SLC50A1; the interaction probably occurs intracellularly and depends on TRPV2 N-glycosylation (By similarity).||SUBCELLULAR LOCATION:Cell membrane; Multi-pass membrane protein (By similarity). Cytoplasm (By similarity). Melanosome. Note=Translocates from the cytoplasm to the plasma membrane upon ligand stimulation (By similarity). Identified by mass spectrometry in melanosome fractions from stage I to stage IV.||PTM:N-glycosylated (By similarity).||PTM:Phosphorylated by PKA (By similarity).||SIMILARITY:Belongs to |
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Subcellular localization |
Cell membrane;Multi-pass membrane protein(By similarity).Cytoplasm(By similarity).Melanosome. |
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Gene name |
transient receptor potential cation channel, subfamily V, member 2 |
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Protein sequence
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MTSPSSSPVFRLETLDGGQEDGSEADRGKLDFGSGLPPME SQFQGEDRKFAPQIRVNLNYRKGTGASQPDPNRFDRDRL FNAVSRGVPEDLAGLPEYLSKTSKYLTDSEYTEGSTGKT CLMKAVLNLKDGVNACILPLLQIDRDSGNPQPLVNAQCT DDYYRGHSALHIAIEKRSLQCVKLLVENGANVHARACGR FFQKGQGTCFYFGELPLSLAACTKQWDVVSYLLENPHQP ASLQATDSQGNTVLHALVMISDNSAENIALVTSMYDGLL QAGARLCPTVQLEDIRNLQDLTPLKLAAKEGKIEIFRHI LQREFSGLSHLSRKFTEWCYGPVRVSLYDLASVDSCEEN SVLEIIAFHCKSPHRHRMVVLEPLNKLLQAKWDLLIPKF FLNFLCNLIYMFIFTAVAYHQPTLKKQAAPHLKAEVGNS MLLTGHILILLGGIYLLVGQLWYFWRRHVFIWISFIDSY FEILFLFQALLTVVSQVLCFLAIEWYLPLLVSALVLGWL NLLYYTRGFQHTGIYSVMIQKVILRDLLRFLLIYLVFLF GFAVALVSLSQEAWRPEAPTGPNATESVQPMEGQEDEGN GAQYRGILEASLELFKFTIGMGELAFQEQLHFRGMVLLL LLAYVLLTYILLLNMLIALMSETVNSVATDSWSIWKLQK AISVLEMENGYWWCRKKQRAGVMLTVGTKPDGSPDERWC FRVEEVNWASWEQTLPTLCEDPSGAGVPRTLENPVLASP PKEDEDGASEENYVPVQLLQSN |
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Database cross reference |
RefSeq Protein accession:NP_057197
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Liver relevance
|
HLPP validation |
Yes/No |
Yes |
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Project name |
Human Fetal Liver;Human Liver Organelles; |
Ontology annotation
| GO-C |
GO:0005887;C:integral to plasma membrane;TAS:ProtInc. GO:0042470;C:melanosome;IEA:UniProtKB-SubCell. |
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GO-F |
GO:0005262;F:calcium channel activity;IEA:UniProtKB-KW. |
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GO-P |
GO:0007600;P:sensory perception;TAS:ProtInc. |
Post-translational modification
| LiverAtlas Protein ID |
MOD type1 |
Position1 |
Residue1 |
Source name1 |
source ID1 |
Source method |
HLPP validation1 (Yes/no) |
Quality score |
|
HuLPr47663 |
PHOSPHORYLATION |
524 |
S |
PhosphoSitePlus |
LTP |
N |
 
|
|
|
HuLPr47663 |
PHOSPHORYLATION |
523 |
Y |
PhosphoSitePlus |
LTP |
N |
|
