HuLPr47670

Uniprot ID

TRUB1_HUMAN

Uniprot Acc

Q8WWH5;B2R716;Q53ES2;

Protein name

Probable tRNA pseudouridine synthase 1

Comment

FUNCTION:May be responsible for synthesis of pseudouridine from uracil in transfer RNAs (By similarity).||CATALYTIC ACTIVITY:tRNA uridine = tRNA pseudouridine.||TISSUE SPECIFICITY:Highly expressed in heart, skeletal muscle and liver. Expressed at lower levels in lung, small intestine, kidney and spleen.||SIMILARITY:Belongs to the pseudouridine synthase TruB family.

Gene name

TruB pseudouridine (psi) synthase homolog 1 (E. coli)

Protein sequence

MAASEAAVVSSPSLKTDTSPVLETAGTVAAMAATPSARAA AAVVAAAARTGSEARVSKAALATKLLSLSGVFAVHKPKG PTSAELLNRLKEKLLAEAGMPSPEWTKRKKQTLKIGHGG TLDSAARGVLVVGIGSGTKMLTSMLSGSKRYTAIGELGK ATDTLDSTGRVTEEKPYDKITQEDIEGILQKFTGNIMQV PPLYSALKKDGQRLSTLMKRGEVVEAKPARPVTVYSISL QKFQPPFFTLDVECGGGFYIRSLVSDIGKELSSCANVLE LTRTKQGPFTLEEHALPEDKWTIDDIAQSLEHCSSLFPA ELALKKSKPESNEQVLSCEYITLNEPKREDDVIKTC

Database cross reference

RefSeq Protein accession:NP_631908
RefSeq Protein gi:21040257

HLPP validation

Yes/No

Yes

Project name

Chinese Liver;Human Liver Organelles;

GO-F

GO:0009982;F:pseudouridine synthase activity;IEA:InterPro. GO:0003723;F:RNA binding;IEA:InterPro.

GO-P

GO:0001522;P:pseudouridine synthesis;IEA:InterPro. GO:0008033;P:tRNA processing;IEA:UniProtKB-KW.

MOD type1

Position1

Residue1

Source name1

source ID1

Source method

HLPP validation1 (Yes/no)

Quality score

HuLPr47670

PHOSPHORYLATION

11

S

PhosphoSitePlus

11536852

LTP

N