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Protein basic information

LiverAtlas Protein ID

HuLPr47725

Uniprot ID

TSP1_HUMAN

Uniprot Acc

P07996;A8K6H4;B9EGH6;Q15667;

Protein name

Thrombospondin-1

Comment

FUNCTION:Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions.||SUBUNIT:Homotrimer; disulfide-linked. Can bind to fibrinogen, fibronectin, laminin, type V collagen and integrins alpha-V/beta- 1, alpha-V/beta-3 and alpha-IIb/beta-3. Binds heparin.||INTERACTION:P21809:BGN (xeno); NbExp=1; IntAct=EBI-2530274, EBI-2566331; P39060:COL18A1; NbExp=1; IntAct=EBI-2530274, EBI-981314; P02751:FN1; NbExp=1; IntAct=EBI-2530274, EBI-1220319; P21980:TGM2; NbExp=1; IntAct=EBI-2530274, EBI-727668;||SIMILARITY:Belongs to the thrombospondin family.||SIMILARITY:Contains 3 EGF-like domains.||SIMILARITY:Contains 1 TSP C-terminal (TSPC) domain.||SIMILARITY:Contains 1 TSP N-terminal (TSPN) domain.||SIMILARITY:Contains 3 TSP type-1 domains.||SIMILARITY:Contains 8 TSP type-3 repeats.||SIMILARITY:Contains 1 VWFC domain.||WEB RESOURCE:Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/THBS1ID42548ch15q15.html";

Gene name

thrombospondin 1

Related liver disease name

Hepatocellular carcinoma

Protein sequence

MGLAWGLGVLFLMHVCGTNRIPESGGDNSVFDIFELTGAA RKGSGRRLVKGPDPSSPAFRIEDANLIPPVPDDKFQDLV DAVRAEKGFLLLASLRQMKKTRGTLLALERKDHSGQVFS VVSNGKAGTLDLSLTVQGKQHVVSVEEALLATGQWKSIT LFVQEDRAQLYIDCEKMENAELDVPIQSVFTRDLASIAR LRIAKGGVNDNFQGVLQNVRFVFGTTPEDILRNKGCSSS TSVLLTLDNNVVNGSSPAIRTNYIGHKTKDLQAICGISC DELSSMVLELRGLRTIVTTLQDSIRKVTEENKELANELR RPPLCYHNGVQYRNNEEWTVDSCTECHCQNSVTICKKVS CPIMPCSNATVPDGECCPRCWPSDSADDGWSPWSEWTSC STSCGNGIQQRGRSCDSLNNRCEGSSVQTRTCHIQECDK RFKQDGGWSHWSPWSSCSVTCGDGVITRIRLCNSPSPQM NGKPCEGEARETKACKKDACPINGGWGPWSPWDICSVTC GGGVQKRSRLCNNPTPQFGGKDCVGDVTENQICNKQDCP IDGCLSNPCFAGVKCTSYPDGSWKCGACPPGYSGNGIQC TDVDECKEVPDACFNHNGEHRCENTDPGYNCLPCPPRFT GSQPFGQGVEHATANKQVCKPRNPCTDGTHDCNKNAKCN YLGHYSDPMYRCECKPGYAGNGIICGEDTDLDGWPNENL VCVANATYHCKKDNCPNLPNSGQEDYDKDGIGDACDDDD DNDKIPDDRDNCPFHYNPAQYDYDRDDVGDRCDNCPYNH NPDQADTDNNGEGDACAADIDGDGILNERDNCQYVYNVD QRDTDMDGVGDQCDNCPLEHNPDQLDSDSDRIGDTCDNN QDIDEDGHQNNLDNCPYVPNANQADHDKDGKGDACDHDD DNDGIPDDKDNCRLVPNPDQKDSDGDGRGDACKDDFDHD SVPDIDDICPENVDISETDFRRFQMIPLDPKGTSQNDPN WVVRHQGKELVQTVNCDPGLAVGY

Database cross reference

RefSeq Protein accession:NP_003237
RefSeq Protein gi:40317626

Liver relevance

HCC significant Proteins

Yes/No

Yes

Quality score

HLPP validation

Yes/No

Yes

Project name

Chinese Liver;Human Liver Organelles;

Ontology annotation

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GO-C

GO:0009897;C:external side of plasma membrane;IDA:BHF-UCL. GO:0031012;C:extracellular matrix;TAS:BHF-UCL. GO:0005577;C:fibrinogen complex;IDA:BHF-UCL. GO:0031093;C:platelet alpha granule lumen;TAS:Reactome.

GO-F

GO:0005509;F:calcium ion binding;NAS:BHF-UCL. GO:0070052;F:collagen V binding;IDA:BHF-UCL. GO:0043499;F:eukaryotic cell surface binding;IDA:BHF-UCL. GO:0070051;F:fibrinogen binding;IDA:BHF-UCL. GO:0048603;F:fibroblast growth factor 2 binding;IDA:BHF-UC

GO-P

GO:0000187;P:activation of MAPK activity;IMP:BHF-UCL. GO:0006916;P:anti-apoptosis;TAS:BHF-UCL. GO:0006915;P:apoptosis;IEP:BHF-UCL. GO:0007155;P:cell adhesion;NAS:BHF-UCL. GO:0007050;P:cell cycle arrest;IDA:BHF-UCL. GO:0016477;P:cell migration;IDA:BHF-