HuLPr47789

Uniprot ID

TTC5_HUMAN

Uniprot Acc

Q8N0Z6;A8MQ18;Q96HF9;

Protein name

Tetratricopeptide repeat protein 5

Comment

FUNCTION:Adapter protein involved in p53/TP53 response that acts by regulating and mediating the assembly of multi-protein complexes. Required to facilitate the interaction between JMY and p300/EP300 and increase p53/TP53-dependent transcription and apoptosis. Prevents p53/TP53 degradation by MDM2 (By similarity).||SUBUNIT:Interacts with JMY and p300/EP300 (By similarity).||SUBCELLULAR LOCATION:Nucleus. Cytoplasm. Note=Phosphorylation at Ser-203 results in nuclear localization, while unphosphorylated protein localizes to the cytoplasm (By similarity).||PTM:Phosphorylation at Ser-203 enhances protein stability, regulates nuclear accumulation and association with p300/EP300 (By similarity).||SIMILARITY:Contains 4 TPR repeats.

Subcellular localization

Nucleus.Cytoplasm.

Gene name

tetratricopeptide repeat domain 5

Protein sequence

MMADEEEEVKPILQKLQELVDQLYSFRDCYFETHSVEDAG RKQQDVQKEMEKTLQQMEEVVGSVQGKAQVLMLTGKALN VTPDYSPKAEELLSKAVKLEPELVEAWNQLGEVYWKKGD VAAAHTCFSGALTHCRNKVSLQNLSMVLRQLRTDTEDEH SHHVMDSVRQAKLAVQMDVHDGRSWYILGNSYLSLYFST GQNPKISQQALSAYAQAEKVDRKASSNPDLHLNRATLHK YEESYGEALEGFSRAAALDPAWPEPRQREQQLLEFLDRL TSLLESKGKVKTKKLQSMLGSLRPAHLGPCSDGHYQSAS GQKVTLELKPLSTLQPGVNSGAVILGKVVFSLTTEEKVP FTFGLVDSDGPCYAVMVYNIVQSWGVLIGDSVAIPEPNL RLHRIQHKGKDYSFSSVRVETPLLLVVNGKPQGSSSQAV ATVASRPQCE

Database cross reference

RefSeq Protein accession:NP_612385
RefSeq Protein gi:226498382

HLPP validation

Yes/No

Yes

Project name

Chinese Liver;

GO:0005737;C:cytoplasm;IEA:UniProtKB-SubCell. GO:0005634;C:nucleus;IEA:UniProtKB-SubCell.

GO-F

GO:0005488;F:binding;IEA:InterPro.

GO-P

GO:0006281;P:DNA repair;IEA:UniProtKB-KW.

MOD type1

Position1

Residue1

Source name1

source ID1

Source method

HLPP validation1 (Yes/no)

Quality score

HuLPr47789

PHOSPHORYLATION

236

Y

PhosphoSitePlus

462745

LTP

N

p53_pathway