Protein basic information
| LiverAtlas Protein ID |
HuLPr47832 |
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Uniprot ID |
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Uniprot Acc |
Q5TAX3;A2RRP0;B7Z8J5;D3DQ35;Q12764;Q5TAX2;Q5TAX4;Q86XZ3; |
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Protein name |
Terminal uridylyltransferase 4 |
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Comment |
FUNCTION:Uridylyltransferase that acts as a suppressor of microRNA (miRNA) biogenesis by specifically mediating the terminal uridylation of some miRNAs. Catalyzes the 3' uridylation of precursor let-7 (pre-let-7), a miRNA precursor. Uridylated pre- let-7 miRNAs fail to be processed by Dicer and undergo degradation. Degradation of pre-let-7 contributes to the maintenance of embryonic stem (ES) cells and is required for ES cells to maintain pluripotency. Does not bind RNA by itself, recruited to pre-let-7 miRNAs via its interaction with LIN28A and LIN28B. Also catalyzes the 3' uridylation of miR-26A, a miRNA that represses IL6 transcript, leading to abrogate IL6 transcript repression and promote cytokine expression. May also suppress Toll-like receptor-induced NF-kappa-B activity via binding to T2BP. Does not play a role in replication-dependent histone mRNA degradation.||CATALYTIC ACTIVITY:UTP + RNA(n) = diphosphate + RNA(n+1).||COFACTOR:Magnesium or manganese (By similarity).||SUBUNIT: |
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Subcellular localization |
Nucleus.Cytoplasm. |
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Gene name |
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Protein sequence
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MEESKTLKSENHEPKKNVICEESKAVQVIGNQTLKARNDK SVKEIENSSPNRNSSKKNKQNDICIEKTEVKSCKVNAAN LPGPKDLGLVLRDQSHCKAKKFPNSPVKAEKATISQAKS EKATSLQAKAEKSPKSPNSVKAEKASSYQMKSEKVPSSP AEAEKGPSLLLKDMRQKTELQQIGKKIPSSFTSVDKVNI EAVGGEKCALQNSPRSQKQQTCTDNTGDSDDSASGIEDV SDDLSKMKNDESNKENSSEMDYLENATVIDESALTPEQR LGLKQAEERLERDHIFRLEKRSPEYTNCRYLCKLCLIHI ENIQGAHKHIKEKRHKKNILEKQEESELRSLPPPSPAHL AALSVAVIELAKEHGITDDDLRVRQEIVEEMSKVITTFL PECSLRLYGSSLTRFALKSSDVNIDIKFPPKMNHPDLLI KVLGILKKNVLYVDVESDFHAKVPVVVCRDRKSGLLCRV SAGNDMACLTTDLLTALGKIEPVFIPLVLAFRYWAKLCY IDSQTDGGIPSYCFALMVMFFLQQRKPPLLPCLLGSWIE GFDPKRMDDFQLKGIVEEKFVKWECNSSSATEKNSIAEE NKAKADQPKDDTKKTETDNQSNAMKEKHGKSPLALETPN RVSLGQLWLELLKFYTLDFALEEYVICVRIQDILTRENK NWPKRRIAIEDPFSVKRNVARSLNSQLVYEYVVERFRAA YRYFACPQTKGGNKSTVDFKKREKGKISNKKPVKSNNMA TNGCILLGETTEKINAEREQPVQCDEMDCTSQRCIIDNN NLLVNELDFADHGQDSSSLSTSKSSEIEPKLDKKQDDLA PSETCLKKELSQCNCIDLSKSPDPDKSTGTDCRSNLETE SSHQSVCTDTSATSCNCKATEDASDLNDDDNLPTQELYY VFDKFILTSGKPPTIVCSICKKDGHSKNDCPEDFRKIDL KPLPPMTNRFREILDLVCKRCFDELSPPCSEQHNREQIL IGLEKFIQKEYDEKARLCLFGSSK |
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Database cross reference |
RefSeq Protein accession:NP_001009881
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Liver relevance
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HLPP validation |
Yes/No |
Yes |
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Project name |
Chinese Liver;Human Liver Organelles; |
Ontology annotation
| GO-C |
GO:0005737;C:cytoplasm;IDA:UniProtKB. GO:0005730;C:nucleolus;IDA:HPA. |
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GO-F |
GO:0003676;F:nucleic acid binding;IEA:InterPro. GO:0005515;F:protein binding;IPI:IntAct. GO:0005515;F:protein binding;IPI:UniProtKB. GO:0050265;F:RNA uridylyltransferase activity;IDA:UniProtKB. GO:0008270;F:zinc ion binding;IEA:InterPro. |
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GO-P |
GO:0010587;P:miRNA catabolic process;IMP:UniProtKB. GO:0031054;P:pre-microRNA processing;IMP:UniProtKB. GO:0031123;P:RNA 3'-end processing;IDA:UniProtKB. GO:0019827;P:stem cell maintenance;IMP:UniProtKB. |
Post-translational modification
| LiverAtlas Protein ID |
MOD type1 |
Position1 |
Residue1 |
Source name1 |
source ID1 |
Source method |
HLPP validation1 (Yes/no) |
Quality score |
|
HuLPr47832 |
PHOSPHORYLATION |
773 |
S |
Phospho-ELM |
HTP |
N |
 
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|
|
HuLPr47832 |
PHOSPHORYLATION |
773 |
S |
PhosphoSitePlus |
HTP |
N |
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|
|
HuLPr47832 |
PHOSPHORYLATION |
104 |
S |
PhosphoSitePlus |
HTP |
N |
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Pathway
| Pathway name |
