Protein basic information
| LiverAtlas Protein ID |
HuLPr47837 |
|
Uniprot ID |
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Uniprot Acc |
Q12792;A8K5A8;B3KXS6;B4DLX9;Q59G07;Q5U0B1;Q6FHJ1;Q6FHL6;Q6NUK9;Q86XL6;Q8TCD3; |
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Protein name |
Twinfilin-1 |
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Comment |
FUNCTION:Actin-binding protein involved in motile and morphological processes. Inhibits actin polymerization, likely by sequestering G-actin. By capping the barbed ends of filaments, it also regulates motility. Seems to play an important role in clathrin-mediated endocytosis and distribution of endocytic organelles (By similarity).||SUBUNIT:Interacts with G-actin; ADP-actin form and capping protein (CP). May also be able to interact with TWF2 and phosphoinositides, PI(4,5)P2. When bound to PI(4,5)P2, it is down- regulated (By similarity).||SUBCELLULAR LOCATION:Cytoplasm. Cytoplasm, cytoskeleton (By similarity). Note=Diffuse cytoplasmic localization with perinuclear and G-actin-rich cortical actin structures sublocalization. Also found at membrane ruffles and cell-cell contacts (By similarity).||ALTERNATIVE PRODUCTS:Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q12792-2; Sequence=Displayed; Name=3; IsoId=Q12792-3; Sequence=VSP 017899; Name=4; IsoId=Q12792-4; Sequence |
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Subcellular localization |
Cytoplasm.Cytoplasm, cytoskeleton(By similarity). |
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Gene name |
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Protein sequence
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MSHQTGIQASEDVKEIFARARNGKYRLLKISIENEQLVIG SYSQPSDSWDKDYDSFVLPLLEDKQPCYILFRLDSQNAQ GYEWIFIAWSPDHSHVRQKMLYAATRATLKKEFGGGHIK DEVFGTVKEDVSLHGYKKYLLSQSSPAPLTAAEEELRQI KINEVQTDVGVDTKHQTLQGVAFPISREAFQALEKLNNR QLNYVQLEIDIKNEIIILANTTNTELKDLPKRIPKDSAR YHFFLYKHSHEGDYLESIVFIYSMPGYTCSIRERMLYSS CKSRLLEIVERQLQMDVIRKIEIDNGDELTADFLYEEVH PKQHAHKQSFAKPKGPAGKRGIRRLIRGPAETEATTD |
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Database cross reference |
RefSeq Protein accession:NP_002813
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Ontology annotation
| GO-C |
GO:0015629;C:actin cytoskeleton;ISS:UniProtKB. GO:0005737;C:cytoplasm;IDA:HPA. |
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GO-F |
GO:0003779;F:actin binding;IEA:UniProtKB-KW. GO:0004713;F:protein tyrosine kinase activity;IDA:UniProtKB. |
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GO-P |
GO:0006468;P:protein phosphorylation;IDA:UniProtKB. |
Post-translational modification
| LiverAtlas Protein ID |
MOD type1 |
Position1 |
Residue1 |
Source name1 |
source ID1 |
Source method |
HLPP validation1 (Yes/no) |
Quality score |
|
HuLPr47837 |
PHOSPHORYLATION |
327 |
Y |
Phospho-ELM |
HTP |
N |
 
|
|
|
HuLPr47837 |
PHOSPHORYLATION |
161 |
S |
Phospho-ELM |
HTP |
N |
|
|
|
HuLPr47837 |
PHOSPHORYLATION |
367 |
T |
Phospho-ELM |
HTP |
N |
|
|
|
HuLPr47837 |
PHOSPHORYLATION |
309 |
Y |
PhosphoSitePlus |
HTP |
N |
|
|
|
HuLPr47837 |
PHOSPHORYLATION |
134 |
Y |
PhosphoSitePlus |
HTP |
N |
|
|
|
HuLPr47837 |
PHOSPHORYLATION |
349 |
T |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr47837 |
PHOSPHORYLATION |
143 |
S |
PhosphoSitePlus |
LTP |
N |
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